DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and STY8

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_179361.1	Gene:	STY8 / 816278	AraportID:	AT2G17700	Length:	546	Species:	Arabidopsis thaliana

Alignment Length:	573	Identity:	156/573 - (27%)
Similarity:	251/573 - (43%)	Gaps:	98/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 KSSSLDAISLSVAISPASSPSPPRPRRSLKQH-RCLQQHQQT-------------------PLAK 1101
            |..|....|.:|..|| |..:|...|..|..: ..||:.|::                   .|..
plant     4 KDESESCGSRAVVASP-SQENPRHYRMKLDVYSEVLQRLQESNYEEATLPDFEDQLWLHFNRLPA 67

  Fly  1102 KHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAH 1166
            :::||..::......:.|.|        ||....|||.  |:..:...:..|...:.|      .
plant    68 RYALDVKVERAEDVLTHQRL--------LKLAADPATR--PVFEVRSVQVSPRISADS------D 116

  Fly  1167 LSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGE------------FLNEKSWYFRKIKRIE 1219
            .:|.:.:.::.:..|...|.....|.|......|:|.            .|:.:..:......|:
plant   117 PAVEEDAQSSHQPSGPGVLAPPTFGSSPNFEAITQGSKIVEDVDSVVNATLSTRPMHEITFSTID 181

  Fly  1220 AEKKL-----LLPE-----NEHGAFLIRDSESRH----NDYSLSVRDG--DTVKHYRIRQLDEGG 1268
            ..|.|     ||.|     .|..||...|..|..    :.:|....||  |.:....::..|:.|
plant   182 KPKLLSQLTSLLGELGLNIQEAHAFSTVDGFSLDVFVVDGWSQEETDGLRDALSKEILKLKDQPG 246

  Fly  1269 FFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRK 1333
                      :.|:.:..:..|...  ..|...|::|.   |:|     .|:||||.|.||..:|
plant   247 ----------SKQKSISFFEHDKSS--NELIPACIEIP---TDG-----TDEWEIDVTQLKIEKK 291

  Fly  1334 LGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP---KDFLAEAQIMKKLRHTKLIQLYAVCTVEEP 1395
            :.||.:||:..|.: .:..||||.||...::.   ::|..|..||:|:||..::|....||....
plant   292 VASGSYGDLHRGTY-CSQEVAIKFLKPDRVNNEMLREFSQEVFIMRKVRHKNVVQFLGACTRSPT 355

  Fly  1396 IYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGD 1460
            :.|:||.|..||:.::|..   :..:.|:|||:.:|..:|.||:||...|.|||||...|:|:.:
plant   356 LCIVTEFMARGSIYDFLHK---QKCAFKLQTLLKVALDVAKGMSYLHQNNIIHRDLKTANLLMDE 417

  Fly  1461 GNIVKIADFGLARL-IKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR 1524
            ..:||:||||:||: |:.....|..|.   .:|.|||...:..::.|:||:|:.|:|.||:| |.
plant   418 HGLVKVADFGVARVQIESGVMTAETGT---YRWMAPEVIEHKPYNHKADVFSYAIVLWELLT-GD 478

  Fly  1525 IPYPGMTNAE-VLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1576
            |||..:|..: .:..|:.|.|...|....|::..::..|||:||.:||.||.:
plant   479 IPYAFLTPLQAAVGVVQKGLRPKIPKKTHPKVKGLLERCWHQDPEQRPLFEEI 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	20/106 (19%)
		PTKc_Frk_like	1319..1587	CDD:270653	98/263 (37%)
		Pkinase_Tyr	1328..1580	CDD:285015	92/254 (36%)
STY8	NP_179361.1	ACT_TyrKc	172..239	CDD:153200	15/66 (23%)
		Pkinase_Tyr	286..535	CDD:285015	92/254 (36%)
		STKc_MAP3K-like	292..535	CDD:270901	89/248 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm3398
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910