DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Frk

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_077344.1	Gene:	Frk / 79209	RGDID:	621423	Length:	506	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	249/388 - (64%)
Similarity:	306/388 - (78%)	Gaps:	5/388 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGF 1269
            |..:.|:|..|||.:|||:||..||:.||||||:|||:..|:||||.|...|||||||:||||||
  Rat   112 LQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGF 176

  Fly  1270 FIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKL 1334
            |:.||.||.||.|.|.:|:..||||||.|.|||::|:.|....||::|.|||||||.|::.:::|
  Rat   177 FLTRRKTFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTVDQWEIDRNSIQLLKRL 241

  Fly  1335 GSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYII 1399
            ||||||:|||||||||||||:||||.|:|||.|||.||||||.|||.||||||||||:|:|||||
  Rat   242 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYII 306

  Fly  1400 TELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIV 1464
            ||||:||||.||||...|.  .:::...:|||||:|:|||||||||||||||||||||||:.||.
  Rat   307 TELMRHGSLQEYLQNDGGS--KIRLTQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIY 369

  Fly  1465 KIADFGLARLIK---EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIP 1526
            |:|||||||:.|   ||.||::...:.|:|||||||...:|||||||||||||||.|::|||::|
  Rat   370 KVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP 434

  Fly  1527 YPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQS 1589
            |.|||.|:|:..:...||:|||.||..:.|.||:|||:.:|.:|||||||.|||||::..|.|
  Rat   435 YSGMTGAQVIHMLGQNYRLPQPSNCPEQFYSIMMECWNVEPKQRPTFETLHWKLEDYFEPDSS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	57/90 (63%)
		PTKc_Frk_like	1319..1587	CDD:270653	181/270 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	169/254 (67%)
Frk	NP_077344.1	SH3_Src_like	48..105	CDD:212779
		SH2_Src_Frk	113..208	CDD:199831	57/94 (61%)
		PTKc_Frk_like	226..495	CDD:270653	181/270 (67%)
		Pkinase_Tyr	235..488	CDD:285015	169/254 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I926
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	589	1.000	Inparanoid score	I957
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto96129
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.970