DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src42A and ptk6b

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001070140.1	Gene:	ptk6b / 767734	ZFINID:	ZDB-GENE-060929-1150	Length:	511	Species:	Danio rerio

Alignment Length:	387	Identity:	181/387 - (46%)
Similarity:	250/387 - (64%)	Gaps:	12/387 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGF 1269
            :..:.|:|.|:.|:.|...|:..||.:|:||:|.|||....|.||||..:..||::|.|..: .|
Zfish   129 VESQPWFFGKMNRVGAVSHLMSDENNYGSFLVRVSESDDMGYVLSVRTKENAKHFKIFQTGD-QF 192

  Fly  1270 FIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKL 1334
            ::.....|.::.|::|||......:...|.:||::| ||  |.:...:.|:||:.:...:...:|
Zfish   193 YVDALFKFSSIVEVIEHYQSHPLSIGDLLSEPCIRI-KP--ENVPPPSTDEWELPKEEFQLENQL 254

  Fly  1335 GSGQFGDVWEGLWNNTTPVAIKTLKSG-TMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYI 1398
            |||.|.||:.|.|.|.:.||||.||:. .:..::|..|.||||:|||..||.|:||||...|.||
Zfish   255 GSGHFADVYSGKWKNHSKVAIKILKNNDALVLREFQLEVQIMKRLRHKHLISLFAVCTSSSPFYI 319

  Fly  1399 ITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNI 1463
            ||||::.|.||.:|:  ..:||||:|::|||||||:|.||||||:.|.|||||||||||||||.:
Zfish   320 ITELIEKGDLLHFLR--NPEGRSLQMESLIDMAAQVADGMAYLEANNSIHRDLAARNVLVGDGYV 382

  Fly  1464 VKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYP 1528
            .|||||||||:|||..|.:. ..:.|.|||||||..:..:|.|||||||||||.|:||:|.||||
Zfish   383 CKIADFGLARIIKEPVYLSD-DKKIPYKWTAPEAIGHGTYSSKSDVWSFGILLYEIVTHGGIPYP 446

  Fly  1529 GMTNAEVLTQV-EHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDF---YTS 1586
            |:...||...: :..||||.||.|...:|.||..||..:.:.||.|:.|:.:|:::   |:|
Zfish   447 GVNTGEVYDLITKENYRMPSPPKCPQAIYNIMRACWRIESVDRPNFKVLKDELDNYQGQYSS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	31/90 (34%)
		PTKc_Frk_like	1319..1587	CDD:270653	144/273 (53%)
		Pkinase_Tyr	1328..1580	CDD:285015	138/253 (55%)
ptk6b	NP_001070140.1	SH3_Brk	70..126	CDD:212781
		SH2	132..216	CDD:214585	30/84 (36%)
		PTKc_Srm_Brk	241..502	CDD:133248	141/263 (54%)
		STYKc	250..499	CDD:214568	138/251 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920