Protein Alignment Src42A and YES1

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_005424.1
• Gene: YES1 / 7525
• HGNCID: 12841
• Length: 543
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 264/560 - (47%)
• Similarity: 338/560 - (60%)
• Gaps: 75/560 - (13%)

  Fly  1090 CLQQHQQTPLAKKHSLDNCLQVVSSTTSR---QPLRRWSNQTPLKCTCHPAT----EELPLTAIE 1147
            |::..:....|.|:..:|..:.||::.|.   :|    :..:|...:....|    ..|.:|...
Human     3 CIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEP----TTVSPCPSSSAKGTAVNFSSLSMTPFG 63

  Fly  1148 KSRSLPAACSASCSHTCAHLSVIDQS-PATTKCFGKTSLTTA-----------------KKGKSR 1194
            .|..:.....||.|     .||:..| ||     |.|...|.                 |||:..
Human    64 GSSGVTPFGGASSS-----FSVVPSSYPA-----GLTGGVTIFVALYDYEARTTEDLSFKKGERF 118

  Fly  1195 RLSEFTRGEFLNEKS------------------------WYFRKIKRIEAEKKLLLPENEHGAFL 1235
            ::...|.|::...:|                        |||.|:.|.:||:.||.|.|:.|.||
Human   119 QIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFL 183

  Fly  1236 IRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLC 1295
            :|:||:....||||:||     ||.||||:||:||.||::|..|..|.|||:||:||::.:||||
Human   184 VRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLC 248

  Fly  1296 VNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKS 1360
            ..|...|..: ||.|:||:   :|.|||.|.||:...|||.|.||:||.|.||.||.|||||||.
Human   249 HKLTTVCPTV-KPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKP 309

  Fly  1361 GTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQ 1425
            |||.|:.||.||||||||||.||:.||||.: ||||||:||.|..||||::|:  .|.|:.||:.
Human   310 GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK--EGDGKYLKLP 371

  Fly  1426 TLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPI 1490
            .|:|||||||.||||:|..|||||||.|.|:|||:..:.|||||||||||:::||.||.||:|||
Human   372 QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPI 436

  Fly  1491 KWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRL 1555
            ||||||||.|.:|:|||||||||||.|||||.||:|||||.|.|||.|||.|||||.|..|...|
Human   437 KWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESL 501

  Fly  1556 YEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595
            :|:|..||.|||..|||||.:|..|||::|:.:..|:..:
Human   502 HELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	50/95 (53%)
		PTKc_Frk_like	1319..1587	CDD:270653	177/267 (66%)
		Pkinase_Tyr	1328..1580	CDD:285015	167/251 (67%)
YES1	NP_005424.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45		9/45 (20%)
		SH3_Yes	94..151	CDD:212940	7/56 (13%)
		SH2_Src_family	154..253	CDD:199827	50/98 (51%)
		PTKc_Yes	264..542	CDD:270654	180/284 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.960