Protein Alignment Src42A and TXK

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_024309968.1
• Gene: TXK / 7294
• HGNCID: 12434
• Length: 530
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 187/525 - (35%)
• Similarity: 283/525 - (53%)
• Gaps: 59/525 - (11%)

  Fly  1090 CL----QQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPA----TEELPLTAI 1146
            ||    :.||...:..:.||....::....|.|:  |.|.:|...|...:..    ::..||..:
Human    16 CLFITKRHHQMRQMRTQISLSTDEELPEKYTQRR--RPWLSQLSNKKQSNTGRVQPSKRKPLPPL 78

  Fly  1147 EKSR-------------SLP-AACSASCSHTCAHLSVIDQSPATTKC---FGKTSLTTAKKGKSR 1194
            ..|.             .|| ..|:.:......:|.:...:|...|.   .|...|..:......
Human    79 PPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTEN 143

  Fly  1195 RLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRH-NDYSLSVRDG----- 1253
            :::.      |....||.|.|.|.:|| .||..|::.|||::||  ||| ..|::||..|
Human   144 KITN------LEIYEWYHRNITRNQAE-HLLRQESKEGAFIVRD--SRHLGSYTISVFMGARRST 199

  Fly  1254 -DTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKP------CVQIEKPVTE 1311
             ..:|||:|::.|.|.:::|.|..|:::.||:.::..::.||...|..|      |:    |.|.
Human   200 EAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCL----PATA 260

  Fly  1312 GLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMK 1376
            |.|:   ::||||.:.|.|::::||||||.|..|.|.:...||||.:..|:|..:||:.||::|.
Human   261 GFSY---EKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMM 322

  Fly  1377 KLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYL 1441
            ||.|:||:|||.||...:|:||:||.|::|.||.||:...||   |:.:.|:.:...|..||.||
Human   323 KLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK---LRKEMLLSVCQDICEGMEYL 384

  Fly  1442 ESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIK 1506
            |...||||||||||.||....||||:|||:.|.:.:|||.:..||:|||||:.||...::|:|.|
Human   385 ERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSK 449

  Fly  1507 SDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRP 1571
            |||||||:|:.|:.|.|::|:...:|.:|:..:..|:|:.:|......:||:|..|||:.|..||
Human   450 SDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRP 514

  Fly  1572 TFETL 1576
            ||..|
Human   515 TFAEL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	36/97 (37%)
		PTKc_Frk_like	1319..1587	CDD:270653	121/258 (47%)
		Pkinase_Tyr	1328..1580	CDD:285015	117/249 (47%)
TXK	XP_024309968.1	SH3_TXK	88..142	CDD:212840	8/53 (15%)
		SH2_Tec_Txk	146..251	CDD:198261	38/113 (34%)
		PTKc_Tec_like	269..524	CDD:173637	119/254 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910