DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and SRMS

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens

Alignment Length:	470	Identity:	203/470 - (43%)
Similarity:	272/470 - (57%)	Gaps:	50/470 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1136 PATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTS------LTTAKKGK-- 1192
            |.|:.:|....|.....|.          ..|::.|   .|.:|.|:.|      |...::|.
Human    36 PNTDPVPTLPAEPCSPFPQ----------LFLALYD---FTARCGGELSVRRGDRLCALEEGGGY 87

  Fly  1193 --SRRLS-EFTRG------------EFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESR 1242
              :|||| :.:.|            |.|:::.|||..:.|.:|::.||.|.||.||||||.|||.
Human    88 IFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESS 152

  Fly  1243 HNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEK 1307
            ...||||||....|.|||:....:|..::.:...|..|:||:.:|..:...:...|.:||:..:.
Human   153 LGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKA 217

  Fly  1308 PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEA 1372
            |        .:|.||...:.....||||.|.||:||||||..:.|||||.:||..|...|...|.
Human   218 P--------RQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEI 274

  Fly  1373 QIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAG--KGRSLKMQTLIDMAAQIA 1435
            |.:|.|||.:||:|:|||:..||:||:||||:.|:    |||..|  :||:|::..|:..|.|:|
Human   275 QTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGN----LQAFLGTPEGRALRLPPLLGFACQVA 335

  Fly  1436 AGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANY 1500
            .||:|||.|..:|||||||||||.||...|:||||||||:|:|.|.....::.|:||||||||||
Human   336 EGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANY 400

  Fly  1501 SKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHK 1565
            ..||.||||||||:||.|:.|||:.||.||||.|.|.|:..|||:|:|..|...:|.:|||||..
Human   401 RVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465

  Fly  1566 DPMRRPTFETLQWKL 1580
            .|..||:|.||:.||
Human   466 SPEERPSFATLREKL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	36/90 (40%)
		PTKc_Frk_like	1319..1587	CDD:270653	144/264 (55%)
		Pkinase_Tyr	1328..1580	CDD:285015	139/253 (55%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780	13/56 (23%)
		SH2	119..197	CDD:301589	34/77 (44%)
		PTKc_Srm_Brk	223..483	CDD:133248	143/262 (55%)
		STYKc	232..480	CDD:214568	139/251 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920