Protein Alignment Src42A and BMX

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 177/557 - (31%)
• Similarity: 283/557 - (50%)
• Gaps: 84/557 - (15%)

  Fly  1061 LDAISLSVAISPASSPS-------PPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTS- 1117
            :||.|.|..::...:.|       ||....||.|:.                .|..::..|..:
Human   182 MDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYD----------------SNSKKIYGSQPNF 230

  Fly  1118 ------RQPLRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPAT 1176
                  |:....|.....||.:   ::.|...::.:|.|::        :||.:.:|.  :.|.:
Human   231 NMQYIPREDFPDWWQVRKLKSS---SSSEDVASSNQKERNV--------NHTTSKISW--EFPES 282

  Fly  1177 TKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSES 1241
                                |.....|.|::..|:...|.|.::| :||..:.:.|||::|:| |
Human   283 --------------------SSSEEEENLDDYDWFAGNISRSQSE-QLLRQKGKEGAFMVRNS-S 325

  Fly  1242 RHNDYSLS-----VRD-GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCK 1300
            :...|::|     |.| ..|||||.:....|...::|....|.::.:|:.::..:|.|:...|..
Human   326 QVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRH 390

  Fly  1301 PCVQTNSFSGVFEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIK 1365
            | |.|.:    .::...|:.|     ...||:.|..:..:::|||||||.|..|.|.....||:|
Human   391 P-VSTKA----NKVPDSVSLG-----NGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVK 445

  Fly  1366 TLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRS 1430
            .:|.|:|...:|..|||.|.||.|.||::.|.||:.|.||||:||.:.:|.||.||::   .|:.
Human   446 MIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRS---HGKG 507

  Fly  1431 LKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGA 1495
            |:...|::|...:..|||:|||..:|||||||||.||.....||::|||:.|.:.:|:|.:.||.
Human   508 LEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGT 572

  Fly  1496 RFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNC 1560
            :||:||:|||..:|.|:|.|||||:||||:.|:.:.|:.||....|::|:.:|..|:|:.:|...
Human   573 KFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLA 637

  Fly  1561 EPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQ 1597
            ...:|:||..|||:.|.:||||:.|...:|.....|:
Human   638 SDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDK 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	28/96 (29%)
		PTKc_Frk_like	1328..1596	CDD:270653	117/267 (44%)
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944
		SH2_Tec_Bmx	289..394	CDD:198262	32/107 (30%)
		PTKc_Btk_Bmx	412..667	CDD:173657	114/257 (44%)
		CAV1-binding	596..603		5/6 (83%)