Protein Alignment Src42A and BLK

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_011542126.1
• Gene: BLK / 640
• HGNCID: 1057
• Length: 531
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 226/441 - (51%)
• Similarity: 291/441 - (65%)
• Gaps: 43/441 - (9%)

  Fly  1184 SLTTAKKGKSRRLSEF-TRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYS 1247
            ||.|.::|...  |.| .|.|.|..:.|:||...|.|||::||.|.|:.|:||||:||:....:|
Human    99 SLVTGREGYVP--SNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFS 161

  Fly  1248 LSVRD----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKP 1308
            |||:|    |:.:|||:||.|||||::|:.|.||.:||.||:||||..||||..|..|||   :|
Human   162 LSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCV---RP 223

  Fly  1309 VTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQ 1373
            ..:  :...:|:|||.|.||:.||||||||||:||.|.:.|...|||||||.|||.|:.||.||.
Human   224 APQ--NPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEAN 286

  Fly  1374 IMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGS--------------------------LLEYL 1412
            :||.|:|.:|::||||.| :|||||:||.|..|.                          ||::|
Human   287 VMKALQHERLVRLYAVVT-KEPIYIVTEYMARGGAPRRAASSERGGRAGLSRRRRVRCGCLLDFL 350

  Fly  1413 QAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKE 1477
            :  ..:|..|.:..||||:||||.||||:|..|.|||||.|.|:||.:....|||||||||:| :
Human   351 K--TDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARII-D 412

  Fly  1478 DEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHG 1542
            .||.|:.||:||||||||||.::..|:||:||||||:||.|:|||||:|||||:|.||:..:|.|
Human   413 SEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERG 477

  Fly  1543 YRMPQPPNCEPRLYE-IMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592
            ||||:|..|.|.||. ::.|||...|..|||||.||..||||||:.:..|:
Human   478 YRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYE 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	51/94 (54%)
		PTKc_Frk_like	1319..1587	CDD:270653	161/294 (55%)
		Pkinase_Tyr	1328..1580	CDD:285015	149/278 (54%)
BLK	XP_011542126.1	SH3_Blk	62..115	CDD:212942	6/17 (35%)
		SH2_Src_Blk	120..219	CDD:198234	51/98 (52%)
		PKc_like	233..522	CDD:304357	159/292 (54%)
		Pkinase_Tyr	241..516	CDD:285015	149/278 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920