DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src42A and tec

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001108215.1	Gene:	tec / 571588	ZFINID:	ZDB-GENE-030131-7499	Length:	622	Species:	Danio rerio

Alignment Length:	618	Identity:	189/618 - (30%)
Similarity:	301/618 - (48%)	Gaps:	91/618 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   993 EETKPKRTQAKRRIGVTN----LLLPLDSEELYTRIIAQQRGLDKEHSQEPEE-KCASEEQMCT- 1051
            |||..||:|.|:|....|    :.:...|:..|..:.|::|  .|:.|.:.:. ||....:..|
Zfish     8 EETLIKRSQQKKRTSPLNYKERVFVLTKSKLTYYELRAEKR--FKKGSVDLQRVKCVEIVKNNTT 70

  Fly  1052 ----RNALTKSSSLDAISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPLA--KKHSLD---- 1106
                :|........|:.:|.:.       :|....||:......::.:..||.  |.||..
Zfish    71 VIPCQNKYPFQVVYDSSTLYIF-------APSNESRSVWVQNIKEEIRNNPLIADKYHSQFWQEG 128

  Fly  1107 ---NCLQV-----------VSSTTSRQPLRRWSNQTPLKCTC--------------HPATEELPL 1143
               .|.||           :....||:||........:.||.              ....||..:
Zfish   129 EWLCCGQVDKLAPGCEGYNLFGDVSRKPLPPVPEDQNISCTGRRPPPPPPGETKQEEEEPEEEVV 193

  Fly  1144 TAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEK 1208
            .|:.....|.       .|... |...::.....||.........|:||    ..:....::.||
Zfish   194 IALYDFEGLE-------PHDLT-LKTGEEYVILEKCEVNWYKARNKEGK----QGYIPSNYVTEK 246

  Fly  1209 S--------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRH----NDYSLSVRDG-DTVKHYR 1260
            :        |:.:.:.|.:|| :||..|.:.|.|::|.|.:..    :.|:.|..|| ..::||:
Zfish   247 ASDKLEQFIWFSKNVNRNKAE-ELLRKEGKEGGFMVRLSSNTGTYTVSLYTKSTSDGAAAIRHYQ 310

  Fly  1261 IRQLDEG--GFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCV---QIEKPVTEGLSHRTRDQ 1320
            |:::...  .|::|.:..|.::.||:|::..::.|| |:..:..|   :.|.|.|.|.|:   |:
Zfish   311 IKEIHASPKQFYLAEKYIFTSIPELIEYHKHNAAGL-VSRLRHAVGDQKREAPTTAGFSY---DK 371

  Fly  1321 WEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQ 1385
            |||:.:.|.|:::|||||||.|..|.|.....|||||::.|.|...||:.||:||..|.|..|:|
Zfish   372 WEINPSELTFMKELGSGQFGVVRLGKWRAQHKVAIKTIREGAMSEDDFIEEAKIMMNLSHRNLVQ 436

  Fly  1386 LYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRD 1450
            ||.|||.::|||::||.|:.|.||.:|:...|   :|..|.|:.:...|:.||.:||...:||||
Zfish   437 LYGVCTQQKPIYLVTEFMELGCLLNFLRQRRG---TLAAQDLLGICHDISQGMQHLEENRFIHRD 498

  Fly  1451 LAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGIL 1515
            |||||.||....:||::|||:.|.:.:|:|.:..|.:||:||:.||..|:.::|.||||||||:|
Zfish   499 LAARNCLVNTSMVVKVSDFGMTRYVLDDQYWSSSGTKFPVKWSPPEVFNFCRYSSKSDVWSFGVL 563

  Fly  1516 LTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQP 1548
            :.|:.|.|::|:....|.||:..|..|:|:.:|
Zfish   564 MWEVFTEGKMPFEHSQNHEVVLMVTQGHRLYRP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	27/97 (28%)
		PTKc_Frk_like	1319..1587	CDD:270653	105/230 (46%)
		Pkinase_Tyr	1328..1580	CDD:285015	101/221 (46%)
tec	NP_001108215.1	PH	6..111	CDD:278594	24/111 (22%)
		PH_Btk	7..148	CDD:269944	32/148 (22%)
		SH3_Tec	192..246	CDD:212838	9/65 (14%)
		SH2_Tec_Itk	249..356	CDD:198259	28/108 (26%)
		PKc_like	374..602	CDD:304357	102/226 (45%)
		Pkinase_Tyr	379..602	CDD:285015	101/221 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910