DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and csk

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001071067.1	Gene:	csk / 556454	ZFINID:	ZDB-GENE-061103-493	Length:	450	Species:	Danio rerio

Alignment Length:	380	Identity:	158/380 - (41%)
Similarity:	230/380 - (60%)	Gaps:	16/380 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1210 WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARR 1274
            |:..||.|.:||:.|..||.  |.||:|:|.:...||:|.|.....|:|||| ....|...|...
Zfish    82 WFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRI-IYHNGKLSIDEE 143

  Fly  1275 TTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQF 1339
            ..|..|.:|:|||:||:||||..|.||  :|.:.........:|..|.::|..||.::.:|.|:|
Zfish   144 EYFENLMQLMEHYTKDADGLCTRLIKP--KIMEGTVAAQDEFSRSGWALNRKELKLIQTIGKGEF 206

  Fly  1340 GDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE-PIYIITELM 1403
            |||..|.:.. ..||:|.:|... ..:.|:|||.:|.:|||..|:||..|...|: .:||:||.|
Zfish   207 GDVMVGDYRG-KKVAVKCIKHDA-TAQAFVAEASVMTQLRHNNLVQLLGVIVEEKGSLYIVTEYM 269

  Fly  1404 KHGSLLEYLQAIAGKGRS-LKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIA 1467
            ..|||::||::   :||: :....||:.:..:...|.|||:.|::|||||||||||.:.||.|::
Zfish   270 AKGSLVDYLRS---RGRTVIGGDRLINFSMDVCKAMEYLEANNFVHRDLAARNVLVSEDNIAKVS 331

  Fly  1468 DFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTN 1532
            ||||.:    :....:..|:.|:|||:|||....|||.||||||:||||.|:.::||:|||.:..
Zfish   332 DFGLTK----EASSTQDTAKLPVKWTSPEALREKKFSTKSDVWSYGILLWEIYSFGRVPYPRIPL 392

  Fly  1533 AEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSD 1587
            .||:.:||.||:|..|..|.|.:|:||.:||..|.:.||:|..|:.||:|..|::
Zfish   393 KEVVPRVEKGYKMDSPDGCPPVVYDIMKQCWTLDAVVRPSFRDLREKLQDIITNE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	38/90 (42%)
		PTKc_Frk_like	1319..1587	CDD:270653	116/269 (43%)
		Pkinase_Tyr	1328..1580	CDD:285015	110/253 (43%)
csk	NP_001071067.1	SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	41/97 (42%)
		PTKc_Csk	188..443	CDD:133213	114/263 (43%)
		STYKc	195..440	CDD:214568	110/253 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910