DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Tyk2

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001192241.1	Gene:	Tyk2 / 54721	MGIID:	1929470	Length:	1207	Species:	Mus musculus

Alignment Length:	332	Identity:	112/332 - (33%)
Similarity:	165/332 - (49%)	Gaps:	47/332 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1272 ARRTTFRT-LQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLG 1335
            |:|.:||| |::|.....::..|      ...|..:.|.:        |.....:..||.:|.||
Mouse   874 AQRPSFRTILRDLTRLQPQNLVG------TSAVNSDSPAS--------DPTVFHKRYLKKIRDLG 924

  Fly  1336 SGQFGDVWEGLWNNTTP-----VAIKTLKSGTMDPK---DFLAEAQIMKKLRHTKLIQLYAVC-- 1390
            .|.||.|....::.|..     ||:|.||.| ..|:   .:..|.:|::.|.|..:::....|
Mouse   925 EGHFGKVSLYCYDPTNDGTGEMVAVKALKEG-CGPQLRSGWQREIEILRTLYHEHIVKYKGCCED 988

  Fly  1391 TVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARN 1455
            ..|:.:.::.|.:..|||.:||..     ..:.:..|:..|.||..|||||.:|:||||||||||
Mouse   989 QGEKSVQLVMEYVPLGSLRDYLPR-----HCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARN 1048

  Fly  1456 VLVGDGNIVKIADFGLARLIKE--DEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTE 1518
            ||:.:..:|||.|||||:.:.|  :.|..|.....|:.|.|||.....||...|||||||:.|.|
Mouse  1049 VLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYE 1113

  Fly  1519 LVTY---GRIPYP------GMTNAEV----LTQ-VEHGYRMPQPPNCEPRLYEIMLECWHKDPMR 1569
            |:||   .:.|:.      |.|..::    ||: :|.|.|:|:|..|...:|.:|..||..:...
Mouse  1114 LLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASF 1178

  Fly  1570 RPTFETL 1576
            ||||:.|
Mouse  1179 RPTFQNL 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	8/29 (28%)
		PTKc_Frk_like	1319..1587	CDD:270653	102/284 (36%)
		Pkinase_Tyr	1328..1580	CDD:285015	101/275 (37%)
Tyk2	NP_001192241.1	B41	45..299	CDD:214604
		PH-like	296..459	CDD:302622
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..391
		SH2	459..557	CDD:301589
		PKc_like	612..887	CDD:304357	6/12 (50%)
		Pkinase_Tyr	612..886	CDD:285015	6/11 (55%)
		PTKc_Tyk2_rpt2	912..1194	CDD:270664	101/280 (36%)
		TyrKc	917..1189	CDD:197581	101/275 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910