DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Src64B

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001286937.1	Gene:	Src64B / 48973	FlyBaseID:	FBgn0262733	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	437	Identity:	216/437 - (49%)
Similarity:	288/437 - (65%)	Gaps:	14/437 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1167 LSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEH 1231
            :.|||.:  .:..:...:|||.::|.. .|:.......:|.:.|:|..:.|.||:|.||..||..
  Fly   122 MEVIDDT--ESDWWRVVNLTTRQEGLI-PLNFVAEERSVNSEDWFFENVLRKEADKLLLAEENPR 183

  Fly  1232 GAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDS 1291
            |.||:|.||...|.|||||:|     |..||||||:.||.||::||...||.:||.||..|||::
  Fly   184 GTFLVRPSEHNPNGYSLSVKDWEDGRGYHVKHYRIKPLDNGGYYIATNQTFPSLQALVMAYSKEN 248

  Fly  1292 D-GLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAI 1355
            . |||..|.:||.: .:|....|....||::||.|:.::.:||||.|.||:|:.|.|.|:..||:
  Fly   249 ALGLCHILSRPCPK-PQPQMWDLGPELRDKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAV 312

  Fly  1356 KTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGR 1420
            |||:.|||....||.||.||||.||.:|:.|||||:.||||||:.|.|..||||::|:  .|.||
  Fly   313 KTLREGTMSTAAFLQEAAIMKKFRHNRLVALYAVCSQEEPIYIVQEYMSKGSLLDFLR--EGDGR 375

  Fly  1421 SLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVG 1485
            .|..:.||.:|.|:|:||.||||:..|||||||||||:|:.|:.||.||||||:|.:|||..:.|
  Fly   376 YLHFEDLIYIATQVASGMEYLESKQLIHRDLAARNVLIGENNVAKICDFGLARVIADDEYCPKQG 440

  Fly  1486 ARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPN 1550
            :|||:|||||||..|.||||||||||:||||.||.|||::|||||.:.||:..:|.|:|||:|.|
  Fly   441 SRFPVKWTAPEAIIYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIENIERGFRMPKPTN 505

  Fly  1551 --CEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595
              ....:|:::|:||...|.:|||||.|....|.|..:.:..|:|.|
  Fly   506 HYFPDNIYQLLLQCWDAVPEKRPTFEFLNHYFESFSVTSEVPYREVQ 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	49/96 (51%)
		PTKc_Frk_like	1319..1587	CDD:270653	150/269 (56%)
		Pkinase_Tyr	1328..1580	CDD:285015	144/253 (57%)
Src64B	NP_001286937.1	SH3_Src_like	99..150	CDD:212779	8/30 (27%)
		SH2_Src_family	158..259	CDD:199827	50/100 (50%)
		STYKc	285..537	CDD:214568	144/253 (57%)
		PTKc_Src_like	289..538	CDD:270630	144/250 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468367
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1725
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.950