Protein Alignment Src42A and Abl

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 620
• Identity: 234/620 - (37%)
• Similarity: 318/620 - (51%)
• Gaps: 107/620 - (17%)

  Fly  1030 GLDKEHSQEPEEKCASEE--QMCTRNALTKSSSLDA------ISLSVAISPASSPSPPRPRRS-- 1084
            ||.:......:.:|....  .:.|.:..||.||...      ::|...:.  |.|.|..|..|
  Fly    85 GLSQRSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQ--SRPLPHIPAGSTA 147

  Fly  1085 ---LKQHRCLQQHQQ---------TPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPA 1137
               |.....||||||         :.|...||        |:|:..:...||:::..|..   |.
  Fly   148 ASLLADAAELQQHQQDSGGLGLQGSSLGGGHS--------STTSVFESAHRWTSKENLLA---PG 201

  Fly  1138 TEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCF----GKTSLTTAKKGKSRRLSE 1198
            .||                              |........:    |..:..:.|||:..|:..
  Fly   202 PEE------------------------------DDPQLFVALYDFQAGGENQLSLKKGEQVRILS 236

  Fly  1199 FTR-GEF-----------------------LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDS 1239
            :.: ||:                       |.:.|||...|.|..||  .||....:|:||:|:|
  Fly   237 YNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE--YLLSSGINGSFLVRES 299

  Fly  1240 ESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS--KDSDGLCVNLCKPC 1302
            ||.....|:|:|....|.||||.:..:|..|:.:...|.||.|||.|:|  .:..||...|..|.
  Fly   300 ESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPA 364

  Fly  1303 VQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLW---NNTTPVAIKTLKSGTMD 1364
            .:..||....||... |:|||.||.:....|||.||:|:|:|.:|   .||  ||:||||..||.
  Fly   365 PKQNKPTVFPLSPEP-DEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT--VAVKTLKEDTMA 426

  Fly  1365 PKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLID 1429
            .||||.||.|||:::|..|:||..|||.|.|.|||||.|.||:||::|:: ||: .:|....|:.
  Fly   427 LKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS-AGR-ETLDAVALLY 489

  Fly  1430 MAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTA 1494
            ||.|||:||:||||:|||||||||||.||||..:||:||||||||:::|.|.|..||:|||||||
  Fly   490 MATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTA 554

  Fly  1495 PEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIM 1559
            ||...|:|||.|||||:||:||.|:.|||..|||.:...:|..:::.||||.:||.|.|.:|::|
  Fly   555 PEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLM 619

  Fly  1560 LECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEA 1594
            .:||..|...||||:::...||..:  .:|...||
  Fly   620 RQCWQWDATDRPTFKSIHHALEHMF--QESSITEA 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	36/92 (39%)
		PTKc_Frk_like	1319..1587	CDD:270653	148/270 (55%)
		Pkinase_Tyr	1328..1580	CDD:285015	140/254 (55%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	7/53 (13%)
		SH2_ABL	268..363	CDD:198189	37/96 (39%)
		PTKc_Abl	382..644	CDD:270645	147/265 (55%)
		Pkinase_Tyr	389..640	CDD:285015	140/254 (55%)
		FABD	1584..1723	CDD:197885

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468396
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950