Protein Alignment Src42A and MATK

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_002369.2
• Gene: MATK / 4145
• HGNCID: 6906
• Length: 508
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 175/533 - (32%)
• Similarity: 250/533 - (46%)
• Gaps: 98/533 - (18%)

  Fly  1080 RPRRS-------LKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPA 1137
            ||||.       |...|.|:.....|:                ::|.|.|||:          |.
Human    13 RPRRGTRGQQQLLVSPRFLRAWHPPPV----------------SARMPTRRWA----------PG 51

  Fly  1138 TEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTT---AKKGKS-RRLSE 1198
            |:                |...|.||        :.......|.|..:.|   |.:.|| .|:..
Human    52 TQ----------------CITKCEHT--------RPKPGELAFRKGDVVTILEACENKSWYRVKH 92

  Fly  1199 FTRGE-------FLNEKS------------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHN 1244
            .|.|:       .|.|:.            |:..||...||.::|..||:  |.||:|:|.....
Human    93 HTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPED--GLFLVRESARHPG 155

  Fly  1245 DYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPV 1309
            ||.|.|..|..|.|||:...| |...|.....|..|.::|||||||...:|..|.:|   ..|..
Human   156 DYVLCVSFGRDVIHYRVLHRD-GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRP---KRKHG 216

  Fly  1310 TEGLSHR-TRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQ 1373
            |:..... .|..|.::...|....::|.|:||.|.:|.:.. ..||:|.:|. .:..:.||.|..
Human   217 TKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG-QKVAVKNIKC-DVTAQAFLDETA 279

  Fly  1374 IMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSL-KMQTLIDMAAQIAAG 1437
            :|.|::|..|::|..| .:.:.:||:.|.:..|:|:.:|:.   :||:| ....|:..:..:|.|
Human   280 VMTKMQHENLVRLLGV-ILHQGLYIVMEHVSKGNLVNFLRT---RGRALVNTAQLLQFSLHVAEG 340

  Fly  1438 MAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSK 1502
            |.||||:..:||||||||:||.:..:.|::|||||:.    |.:....:|.|:|||||||..:.|
Human   341 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGK 401

  Fly  1503 FSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDP 1567
            |:.||||||||:||.|:.:|||.|||.|:..||...||.||||..|..|...::.:|..||..:|
Human   402 FTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEP 466

  Fly  1568 MRRPTFETLQWKL 1580
            .|||.|..|..||
Human   467 ARRPPFRKLAEKL 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	36/90 (40%)
		PTKc_Frk_like	1319..1587	CDD:270653	105/263 (40%)
		Pkinase_Tyr	1328..1580	CDD:285015	102/252 (40%)
MATK	NP_002369.2	SH3_CHK	51..109	CDD:212745	15/81 (19%)
		SH3 domain	55..106		12/58 (21%)
		SH2_csk_like	119..216	CDD:198190	38/102 (37%)
		SH2 domain	123..213		37/95 (39%)
		PTKc_Chk	229..482	CDD:270666	105/261 (40%)
		catalytic domain	236..479		102/252 (40%)
		STYKc	236..479	CDD:214568	102/252 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910