Protein Alignment Src42A and Csk

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001262476.1
• Gene: Csk / 41398
• FlyBaseID: FBgn0262081
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1257
• Identity: 317/1257 - (25%)
• Similarity: 490/1257 - (38%)
• Gaps: 329/1257 - (26%)

  Fly   425 SYQAGSP----VDLLCAPNEENTLVETPPATSAKPCIPGSNNSSRKTSFDSTSTLSSMDSGFMEM 485
            ||...:|    .|...:.:.|..|  .|.:.||.|  ..|||.|     |::.|.|
  Fly    18 SYLMPTPSPSGADATVSSSLERVL--KPASASASP--SNSNNES-----DNSQTSS--------- 64

  Fly   486 QNKLDALAAAAAATLIGESTPPLGEAAAPLGEAAPSSAIGEKIDRRNYKECLTQSRNRRKSYEEF 550
                                   |...|.......:.::|     |:::..:.|...||..:...
  Fly    65 -----------------------GSQTASSASKRSNRSVG-----RSHRGSIAQDTRRRYYFGSK 101

  Fly   551 KAMFIEPPAEASKSVTVPPPVVAPADDATTASSTVIPLSSISEQENIGSRGV---RGKPD--CAN 610
            ...:.:...||:.:.|:      .....|.::|:|....:.:...:.|.:.:   |.||.  |::
  Fly   102 DIYWCKQSREAAAAATL------SGSGLTRSASSVTHKEASTHATHTGGQVISRARRKPILLCSS 160

  Fly   611 EFTAST----------DEMDTGDGNSDGEKGAAAEVDLTTETTATAKTLVSSSTTEAMRKNSDFL 665
            ...|..          |:.         ..|.|.....||.|:||:....||...:|
  Fly   161 LSAAYAPPRRREFYFCDKY---------APGPARSTPTTTTTSATSAKHESSPPIDA-------- 208

  Fly   666 SQILDHQFAAKERAKAHKRRTSYEEFK-RLVNEIEPLECPNTQPTVSAAVTPTTAT-----AAAA 724
             ::|:....|..:.:|.|.:|..::.| |.:.........|.|.| |.::.|..::     ..|.
  Fly   209 -RLLNFLRCAHRKFQASKAKTELQQTKDRFLGNSRERTSKNGQQT-SRSLPPIASSEEWFDEEAQ 271

  Fly   725 ASLIKRQNSRQRKSFASYFLPHRHSTKEQKTEKENCSRDPIKPSQEQQLAVCGKLPLHRSNTSDI 789
            |.....:.|::.|.          ..:|...|||..||   |.|.|..|..
  Fly   272 ARKTSHEKSQKPKP----------KPEENHKEKEAISR---KASGEGDLIT-------------- 309

  Fly   790 SSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYG--------------TIYEILHRKT 840
                                   ::.|..:.:|.....|.|              |.....||..
  Fly   310 -----------------------VEIKQGLLRKQTATTTTGQAMNSHATATQNGQTTVVGHHRGF 351

  Fly   841 SQSSDPWQRKSLSSILEGGRSSGD--IIYDIGQRR------ERDKR-------TLGSSSSATVST 890
            ||.|     .::::....|.::||  .:...|.:.      ..:||       .||:.||.|.
  Fly   352 SQPS-----VTVAAAAATGSTAGDPWFLQTTGHQMPPTAPLRHNKRPAPQPNAVLGAGSSGTA-- 409

  Fly   891 INPHKYGTIYDILQGVKIDAGHVKNKPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSV 955
                         .|..:.|..:..:...:|:|.               :.|..|||.....:..
  Fly   410 -------------PGSAVGAVLLHQQQLSQSQPH---------------IVPPSIPPHHHHHREN 446

  Fly   956 Q----EQGAPKS--------NKPNKMRRLSNILSYSRNSGEDQQETTGKEETKPKRTQAKRRIGV 1008
            .    :.||..:        |..|.:...||....|.:..:.||:||.::: :.::.||...|..
  Fly   447 NVHPIQAGAAAALHLSSHALNSHNLISSASNHSPKSPSQTQQQQQTTNQQQ-QQQQQQASHSILS 510

  Fly  1009 T-------NLLLPLDSEEL-----YTRIIAQQRGLDKEHSQ-----EPEEKCASEEQMCTRNALT 1056
            |       ..:.|..|:.:     ....:|||:  .::|.|     .|            ..|..
  Fly   511 TFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQ--QQQHLQLLANCPP------------GGAGL 561

  Fly  1057 KSSSLDAISLSVAISPASSPSPPRP-RRSLKQH---RCLQQHQQTPLAKKHSLDNCLQVVSSTTS 1117
            .||||:|..:  .:..|....||:. ..|..||   ..|....|.|.|.:.:     .||..:
  Fly   562 MSSSLNAAQM--GMHGAERALPPKSLALSGSQHGSNMLLHTAPQPPQASQPA-----AVVGVS-- 617

  Fly  1118 RQPLRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCA--HLSVIDQSPATTKCF 1180
                  .|....:..:.|    ...:..:.....:.|:.:.|...|.|  |.|:   ||
  Fly   618 ------GSGSAGMSTSLH----SFDINGVTAGSGVNASSAWSSGSTTAMNHASL---SP------ 663

  Fly  1181 GKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHND 1245
              |:| ..::|:||...:      ||...|:...|.|.|||.  ||...|.|.||:|:|.:...|
  Fly   664 --TAL-APQQGRSRCEVK------LNAMPWFHGSITRDEAEH--LLQPREDGLFLVRESTNFPGD 717

  Fly  1246 YSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNL--CKP------- 1301
            |:|.|.....|:|||::.| |....|.....|..|.:||.||..|:||||..|  |.|
  Fly   718 YTLCVCFQSKVEHYRVKYL-ENKLTIDDEEYFENLGQLVAHYEADADGLCTQLIKCLPKLGKQEF 781

  Fly  1302 CVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLK-SGTMDP 1365
            |:..:..|.:|        |.|....|:....:|.|:||||..|:..| ..||:|.|| .|.:
  Fly   782 CINSKDFVDKG--------WVIPEAELQLRESIGKGEFGDVMLGILRN-EKVAVKMLKDEGAV-- 835

  Fly  1366 KDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRS-LKMQTLID 1429
            :.|||||.:|..|.|..|::...:....:.:|::||.|..|||::||::   :||. :..:..|.
  Fly   836 QKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYMSKGSLVDYLRS---RGRQHITKKDQII 897

  Fly  1430 MAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTA 1494
            .|...|:||.|||::..:||||||||||:.:..:.|::||||||   |:.|...|| :.||||||
  Fly   898 FAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFGLAR---EECYNLDVG-KLPIKWTA 958

  Fly  1495 PEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIM 1559
            |||....:||.|||:|||||||.|:.::||:|||.:..|:|:..||.||:|..|..|.|.:||:|
  Fly   959 PEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMM 1023

  Fly  1560 LECWHKDPMRRPTFETLQWKLE 1581
            .:.|..:|.:||||..|:.||:
  Fly  1024 RQAWDLNPAKRPTFAELKVKLQ 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	38/92 (41%)
		PTKc_Frk_like	1319..1587	CDD:270653	115/265 (43%)
		Pkinase_Tyr	1328..1580	CDD:285015	111/253 (44%)
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	40/99 (40%)
		PTKc_Csk_like	793..1047	CDD:270635	115/263 (44%)
		STYKc	800..1044	CDD:214568	111/253 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468359
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950