DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Src42A and FER

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	1360	Identity:	299/1360 - (21%)
Similarity:	488/1360 - (35%)	Gaps:	436/1360 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 SEAFSLLPTTARSTSLTET-------ALAKTAATVLPLYAVVSKNR--ELESITKTVEVPTSAML 390
            :|.:...|||.......||       .|..:..||..|.....:||  |||...:..:.....|:
  Fly   269 TEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGAVRDCQEKQMKMI 333

  Fly   391 AVV----------LEETSSHTADG----RDLI--SFDDDQAQVCAEAGYVSYQAGSPVDLL-CAP 438
            ..|          :....|:|::|    :|.:  ...|..|..|.|.     |....||:: ||.
  Fly   334 EHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEK-----QKQKLVDMIKCAL 393

  Fly   439 NE----------------ENTLVETPPATSAKPCIPGSNNSSRKTSFDSTSTLSSMDSGFMEMQN 487
            ||                |...:|.           |.||..::::..|:..|..|:
  Fly   394 NEVGCEELPSGCDDDLTLEQNFIEN-----------GYNNEQQRSNSTSSPGLGIMN-------- 439

  Fly   488 KLDALAAAAAATLI--------GESTPPLGEAAAPLGEAAPSSAIGEKIDRRNYKECLTQSRNRR 544
              :.:......||:        .:|||   :.|.|:                        :|:|:
  Fly   440 --ELMRRGGVLTLLRGRGRHFKRKSTP---QPATPM------------------------TRSRQ 475

  Fly   545 KSYEEFKAMFIEPPAEASKSVTV------PPPVVAPADDATTASSTVIPLSSISEQENIGSRGVR 603
            ..:.:     ::|.:::..|::|      |.|                     :..|.|.:..:|
  Fly   476 GRFNK-----LQPRSQSLGSLSVIRDGNGPSP---------------------ARYEPITNHRLR 514

  Fly   604 GKPDCANEFTASTDEMDTGDGNSDGEKGAAAEVDLTTETTATAKTLVSSSTTEAMRKNSDFLSQI 668
                                        .||.|....|..||:.|            |...|:::
  Fly   515 ----------------------------QAASVHYLGEEIATSST------------NPPDLTRL 539

  Fly   669 LDHQFAAKERAKAHKRRTSYEEFKRLVNEIEPLEC------PNTQPTVSAAVTPTTATAAAAASL 727
                           |||               :|      .:.:|.|.|:..|.|...||..:
  Fly   540 ---------------RRT---------------QCSMLCLGEDEEPVVLASPAPLTQLTAAVLT- 573

  Fly   728 IKRQNSRQRKSFASYFLPHRHSTKEQKTEKENCSRDPIKPSQEQ------QLAVCGKLPLHRSNT 786
                |:.....:|...|    ..|:..:....|..:.|:|.:||      |.|....:..|....
  Fly   574 ----NTNNNHIYADLEL----DKKKDTSPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRI 630

  Fly   787 SDISSSYYRRNFKIYDKLVYGTIYDIIQRKNDIYQKYDKYMTYGTIYEILHRKTSQSSDPWQRKS 851
            .:::        ::.|..:..|    :|..:|:     ..:.......|..||.::..|...::|
  Fly   631 DELN--------RVLDDRLKRT----LQPSDDV-----NAIESAEENHIQTRKLAKDPDSQTKRS 678

  Fly   852 LSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINPHKYGTIYDILQG--VKIDAGHVK 914
            .||..| .|||.|..:.       .||:| |.|..::|.|    :..:.:..:.  |::...|:.
  Fly   679 SSSSSE-CRSSKDTSHS-------KKRSL-SFSQKSISNI----FSNLKEFSKSPLVRMGKNHIL 730

  Fly   915 NKPDQKSKPTKPP----------------------------------LAKPTRFVVSQVVEPVQI 945
            |: :|.:|.|:|.                                  .|..:..:.|.:...:..
  Fly   731 NE-EQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITT 794

  Fly   946 PPTDQSGK--SVQEQGAPKSNKPNKMRR---LSNILSYSRNSGEDQQETTGKEETKPKRTQAKRR 1005
            ..|....|  |..:...||..|.:|..|   .|.:|::.            .:.:||.:...|||
  Fly   795 TTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQ------------LKRSKPCKQCTKRR 847

  Fly  1006 IGVTNLLLPLDSEELYTRIIAQQRGLD--KEHSQEPEEKCASEEQMCTRNALTKSSSLDAISLSV 1068
                             ||...:...|  ||...|.....|::||.|.
  Fly   848 -----------------RIHPSKSVFDFAKEFEVEQPAGSAADEQFCN----------------- 878

  Fly  1069 AISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCT 1133
              .|.:...|.:|...:..|            |.|..::....:...:.|.
  Fly   879 --CPPAGQKPVKPSVQISGH------------KDHPFESSSGELDENSDRD-------------- 915

  Fly  1134 CHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSE 1198
                        |:.......:.|...      ||:.|............||:|.:.
  Fly   916 ------------IDNDEEEEDSASDDV------LSMKDHCYCVPSLAASISLSTNRP-------- 954

  Fly  1199 FTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDS-ESRHNDYSLSV-RDGDTVKHYRI 1261
                  |.|:.|:...:.|.|..:.|    |..|.||:|:: .:..:...||| .:|.  ||:.:
  Fly   955 ------LYEEEWFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGH--KHFIV 1007

  Fly  1262 RQLDEGGFFIARRTTFRTLQELVEH-YSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDR 1325
            :...||.|.. ....|.::|||:.| |..:   |.|.: |....:.:||       .|::||:..
  Fly  1008 QTTGEGNFRF-EGPPFASIQELIMHQYHSE---LPVTV-KSGAILRRPV-------CRERWELSN 1060

  Fly  1326 TSLKFVRKLGSGQFGDVWEGLWNNT-TPVAIKTLKSGTMD--PKDFLAEAQIMKKLRHTKLIQLY 1387
            ..:..:.::|.|.||||::....:| ..||:||.:....|  .:.||.|.:|:|:..|..:::|.
  Fly  1061 DDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLI 1125

  Fly  1388 AVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLA 1452
            .:|..::||.|:.||:..||||.||:.   ....|..:..:.|....||||.||||:|.||||||
  Fly  1126 GICVQKQPIMIVMELVLGGSLLTYLRK---NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLA 1187

  Fly  1453 ARNVLVGDGNIVKIADFGLARLIKEDEYEARVGAR-FPIKWTAPEAANYSKFSIKSDVWSFGILL 1516
            |||.||...:.|||:|||::|  :|:||....|.: .|:|||||||.|:.|::...||||:|||:
  Fly  1188 ARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILM 1250

  Fly  1517 TELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1576
            .|:.:.|..||.||||:....:::.|||||.|.:....:|.:||:||..|...||.|:.:
  Fly  1251 WEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	26/93 (28%)
		PTKc_Frk_like	1319..1587	CDD:270653	106/262 (40%)
		Pkinase_Tyr	1328..1580	CDD:285015	104/253 (41%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/109 (25%)
		TyrKc	1063..1311	CDD:197581	104/253 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	104/249 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468374
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950