Protein Alignment Src42A and LYN

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_011515831.1
• Gene: LYN / 4067
• HGNCID: 6735
• Length: 682
• Species: Homo sapiens
• Alignment Length: 695
• Identity: 269/695 - (38%)
• Similarity: 375/695 - (53%)
• Gaps: 122/695 - (17%)

  Fly   954 SVQEQGAPKSNKPNKMR--RLSNILSYSRNSGEDQQETTGKEETKPKRTQAKRRIGVTNLLLPLD 1016
            |:||:..|..:.|...|  |..::.|....:.....:|.|:::|            ||:   |..
Human    53 SLQEKAGPGCSTPRSCRLSRQVSVPSKPCATATPNTQTLGRDQT------------VTS---PPS 102

  Fly  1017 SEELYTRIIAQQRGLDKEHSQEPEEKCASEEQMCTRNALTKSSSLDAISLS--VAISPAS----- 1074
            ...:..|    ..|...:.|.||.     :.|..:|.|..:..||.....|  .|:.|.:
Human   103 GLNMQIR----APGSSWDLSAEPR-----DSQFLSRRAGPRCRSLPGRGASGPDALQPPARGKRG 158

  Fly  1075 -----SPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQ--------------- 1119
                 .|:|..|||:.........|.|..|.:        .|...|.:..
Human   159 GRATPGPAPAAPRRASSVPGQQPPHTQVLLGR--------PVAPPTLNSSHRGAPPPRNFHRERV 215

  Fly  1120 ------PLRRWSNQTPLK-----------CTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHL 1167
                  |.:|:..:.|.:           ...||  ::|.....||                  :
Human   216 PESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHP--DDLSFKKGEK------------------M 260

  Fly  1168 SVIDQSPATTKCFGKTSLTTAKKG--KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENE 1230
            .|:::.....|.   .||.|.|:|  .|..:::...   |..:.|:|:.|.|.:||::||.|.|.
Human   261 KVLEEHGEWWKA---KSLLTKKEGFIPSNYVAKLNT---LETEEWFFKDITRKDAERQLLAPGNS 319

  Fly  1231 HGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKD 1290
            .||||||:||:....:||||||     ||.:|||:||.||.||::|:.|.||..:.::::||.|.
Human   320 AGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQ 384

  Fly  1291 SDGLCVNLCKPCV--QIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPV 1353
            :||||..|.|.|:  :.:||       ..:|.|||.|.|:|.|::||:||||:||.|.:||:|.|
Human   385 ADGLCRRLEKACISPKPQKP-------WDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 442

  Fly  1354 AIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGK 1418
            |:||||.|||..:.||.||.:||.|:|.||::||||.|.|||||||||.|..||||::|:  :.:
Human   443 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK--SDE 505

  Fly  1419 GRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEAR 1483
            |..:.:..|||.:||||.||||:|.:|||||||.|.||||.:..:.|||||||||:|:::||.||
Human   506 GGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAR 570

  Fly  1484 VGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQP 1548
            .||:||||||||||.|:..|:||||||||||||.|:||||:|||||.|||:|:|.:..|||||:.
Human   571 EGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV 635

  Fly  1549 PNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKE 1593
            .||...||:||..||.:....||||:.||..|:||||:.:..|::
Human   636 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQ 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	47/95 (49%)
		PTKc_Frk_like	1319..1587	CDD:270653	163/267 (61%)
		Pkinase_Tyr	1328..1580	CDD:285015	152/251 (61%)
LYN	XP_011515831.1	SH3_Lyn	237..292	CDD:212937	13/77 (17%)
		SH2_Src_Lyn	295..395	CDD:198227	47/99 (47%)
		PTKc_Lyn	409..680	CDD:270657	163/272 (60%)
		Pkinase_Tyr	417..667	CDD:285015	152/251 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920