Protein Alignment Src42A and LCK

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: XP_024302814.1
• Gene: LCK / 3932
• HGNCID: 6524
• Length: 567
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 231/434 - (53%)
• Similarity: 302/434 - (69%)
• Gaps: 23/434 - (5%)

  Fly  1167 LSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEF---TRGEFLNEKSWYFRKIKRIEAEKKLLLPE 1228
            |.:::||....|.   .||||.::|    ...|   .:...|..:.|:|:.:.|.:||::||.|.
Human   146 LRILEQSGEWWKA---QSLTTGQEG----FIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPG 203

  Fly  1229 NEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288
            |.||:||||:|||....:||||||     |:.||||:||.||.|||:|:.|.||..|.|||.||:
Human   204 NTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT 268

  Fly  1289 KDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPV 1353
            ..|||||..|.:|| |.:||....    ..|:||:.|.:||.|.:||:||||:||.|.:|..|.|
Human   269 NASDGLCTRLSRPC-QTQKPQKPW----WEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV 328

  Fly  1354 AIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGK 1418
            |:|:||.|:|.|..|||||.:||:|:|.:|::||||.| :||||||||.|::|||:::|:  ...
Human   329 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK--TPS 390

  Fly  1419 GRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEAR 1483
            |..|.:..|:|||||||.|||::|.:|||||||.|.|:||.|....|||||||||||:::||.||
Human   391 GIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAR 455

  Fly  1484 VGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQP 1548
            .||:||||||||||.||..|:||||||||||||||:||:||||||||||.||:..:|.||||.:|
Human   456 EGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRP 520

  Fly  1549 PNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592
            .||...||::|..||.:.|..||||:.|:..||||:|:.:..|:
Human   521 DNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQ 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	52/95 (55%)
		PTKc_Frk_like	1319..1587	CDD:270653	162/267 (61%)
		Pkinase_Tyr	1328..1580	CDD:285015	153/251 (61%)
LCK	XP_024302814.1	SH3_Lck	123..176	CDD:212938	10/36 (28%)
		SH2_Src_Lck	181..281	CDD:198225	52/99 (53%)
		PTKc_Lck_Blk	295..558	CDD:270652	160/265 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6834
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920