DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and fyna

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001315092.1	Gene:	fyna / 373872	ZFINID:	ZDB-GENE-030903-5	Length:	537	Species:	Danio rerio

Alignment Length:	514	Identity:	254/514 - (49%)
Similarity:	324/514 - (63%)	Gaps:	72/514 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1136 PATEELP---LTAIEKSRSLPAACSA---------SCSHTCAHLSVIDQSPATTKCFGKTSLT-- 1186
            |..:..|   :|||....:..|..|.         |.||:           .|.:..|.|.:|
Zfish    34 PTPQHYPSFGVTAIPNYNNFHAPVSQGVTVFGGVNSSSHS-----------GTLRSRGGTGVTLF 87

  Fly  1187 --------------TAKKGKSRRLSEFTRGEFLNEKS------------------------WYFR 1213
                          :.:||:..::...|.|::...:|                        |||.
Zfish    88 VALYDYEARSEDDLSFRKGEKFQILNSTEGDWWEARSLTTGGTGYIPSNYVAPVDSIQAEDWYFG 152

  Fly  1214 KIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIAR 1273
            |:.|.:||::||...|..|.||||:||:....||||::|     ||.||||:||:||.||::|..
Zfish   153 KLGRKDAERQLLSNGNPRGTFLIRESETTKGAYSLSIQDWDETKGDHVKHYKIRKLDNGGYYITT 217

  Fly  1274 RTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQ 1338
            |..|.|||:||.|||..:.|||..|..||.: ..|....||.:|:|.|||.|.||:.:::||:||
Zfish   218 RAQFETLQQLVHHYSARAAGLCCRLIVPCHK-GMPRLADLSVKTKDVWEIPRESLQLIKRLGNGQ 281

  Fly  1339 FGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELM 1403
            ||:||.|.||..|.||:||||.|||.|:.||.||||||||||.||:|||||.: ||||||:||.|
Zfish   282 FGEVWMGTWNGNTKVAVKTLKPGTMSPESFLEEAQIMKKLRHDKLVQLYAVVS-EEPIYIVTEYM 345

  Fly  1404 KHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIAD 1468
            ..||||::|:  .|:||.||:..|:|||||:||||||:|..|||||||.:.|:||||..:.||||
Zfish   346 SKGSLLDFLK--DGEGRGLKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGDSLVCKIAD 408

  Fly  1469 FGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNA 1533
            |||||||:::||.||.||:|||||||||||.|.:|:|||||||||||||||||.||:|||||.|.
Zfish   409 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNR 473

  Fly  1534 EVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592
            |||.|||.|||||.|.:|...|:|:||:||.:||..|||||.||..|||::|:.:..|:
Zfish   474 EVLEQVERGYRMPCPQDCPSSLHELMLQCWKRDPEERPTFEYLQAFLEDYFTATEPQYQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	49/95 (52%)
		PTKc_Frk_like	1319..1587	CDD:270653	179/267 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	169/251 (67%)
fyna	NP_001315092.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..34		254/514 (49%)
		SH3_Fyn_Yrk	85..140	CDD:212939	6/54 (11%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	49/99 (49%)
		PTKc_Fyn	261..534	CDD:270655	180/275 (65%)
		Pkinase_Tyr	271..520	CDD:285015	169/251 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.930