DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and JAK3

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_000206.2	Gene:	JAK3 / 3718	HGNCID:	6193	Length:	1124	Species:	Homo sapiens

Alignment Length:	296	Identity:	105/296 - (35%)
Similarity:	156/296 - (52%)	Gaps:	29/296 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1318 RDQWEIDRTSLKFVRKLGSGQFGDV----WEGLWNNT-TPVAIKTLK-SGTMDPKDFLAEAQIMK 1376
            :|....:...||::.:||.|.||.|    ::.|.:|| ..||:|.|: ||....:||..|.||:|
Human   812 QDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILK 876

  Fly  1377 KLRHTKLIQLYAVCTV---EEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGM 1438
            .| |:..|..|...:.   .:.:.::.|.:..|.|.::||....:   |....|:..::||..||
Human   877 AL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR---LDASRLLLYSSQICKGM 937

  Fly  1439 AYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARL--IKEDEYEARVGARFPIKWTAPEAANYS 1501
            .||.|:..:||||||||:||.....|||||||||:|  :.:|.|..|...:.||.|.|||:.:.:
Human   938 EYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDN 1002

  Fly  1502 KFSIKSDVWSFGILLTELVTY------GRIPYPGMTNAE--------VLTQVEHGYRMPQPPNCE 1552
            .||.:|||||||::|.||.||      ....:..|...|        :|..:|.|.|:|.||.|.
Human  1003 IFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACP 1067

  Fly  1553 PRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQ 1588
            ..::|:|..||...|..||:|..|..:|:..::..:
Human  1068 AEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSR 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233
		PTKc_Frk_like	1319..1587	CDD:270653	105/292 (36%)
		Pkinase_Tyr	1328..1580	CDD:285015	103/276 (37%)
JAK3	NP_000206.2	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..223
		B41	39..>200	CDD:214604
		PH-like	250..362	CDD:302622
		SH2_Jak3	362..458	CDD:198243
		PTK_Jak3_rpt1	521..778	CDD:271110
		Pkinase_Tyr	521..777	CDD:285015
		PTKc_Jak3_rpt2	817..1099	CDD:270665	104/285 (36%)
		Pkinase_Tyr	822..1095	CDD:285015	103/276 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910