DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and ITK

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_005537.3	Gene:	ITK / 3702	HGNCID:	6171	Length:	620	Species:	Homo sapiens

Alignment Length:	407	Identity:	158/407 - (38%)
Similarity:	241/407 - (59%)	Gaps:	27/407 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1199 FTRGEFLNEKS--------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSV----- 1250
            :....:|.|||        ||.:.|.|.:|| ||||...:.|||::|||.:. ..|::||
Human   220 YVPSSYLVEKSPNNLETYEWYNKSISRDKAE-KLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAV 282

  Fly  1251 --RDGDTVKHYRIRQLDEG--GFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKP-CVQIEK-PV 1309
              .:...:|||.|::.::.  .:::|.:..|.::..|:.::..:..||...|..| |...:| ||
Human   283 VSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPV 347

  Fly  1310 TEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQI 1374
            |.||.:   .:|.||.:.|.||:::||||||.|..|.|.|...|||||::.|.|..:||:.||::
Human   348 TAGLRY---GKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEV 409

  Fly  1375 MKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMA 1439
            |.||.|.||:|||.||..:.||.::.|.|:||.|.:||:...|   ....:||:.|...:..|||
Human   410 MMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG---LFAAETLLGMCLDVCEGMA 471

  Fly  1440 YLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFS 1504
            |||....|||||||||.|||:..::|::|||:.|.:.:|:|.:..|.:||:||.:||..::|::|
Human   472 YLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYS 536

  Fly  1505 IKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMR 1569
            .||||||||:|:.|:.:.|:|||...:|:||:..:..|:|:.:|......:|:||..||.:.|..
Human   537 SKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPED 601

  Fly  1570 RPTFETLQWKLEDFYTS 1586
            ||.|..|..:|.:...|
Human   602 RPAFSRLLRQLAEIAES 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	29/99 (29%)
		PTKc_Frk_like	1319..1587	CDD:270653	117/268 (44%)
		Pkinase_Tyr	1328..1580	CDD:285015	112/251 (45%)
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841	1/8 (13%)
		SH2_Tec_Itk	232..340	CDD:198259	30/109 (28%)
		PTKc_Itk	358..613	CDD:133243	114/257 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910