Protein Alignment Src42A and Btk

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001007799.2
• Gene: Btk / 367901
• RGDID: 1359683
• Length: 661
• Species: Rattus norvegicus
• Alignment Length: 655
• Identity: 201/655 - (30%)
• Similarity: 317/655 - (48%)
• Gaps: 93/655 - (14%)

  Fly   998 KRTQAKRRIGVTN-----LLLPLDSEELYTRIIAQQRGLDKEHSQE-----------PEEKCASE 1046
            ||:|.|::....|     .||.:.....|.....:.|...|:.|.:           ||:....|
  Rat    12 KRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPE 76

  Fly  1047 EQMCTRNALTKSSSLDAISLSVAISP-------------ASSPSPPRPRRSLKQHRCLQQHQQTP 1098
            .|:.......:||.::.||: :...|             ..||:....:|.:.|.:.:.::....
  Rat    77 RQIPVPRRGEESSEMEQISI-IERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDL 140

  Fly  1099 LAKKHS---LDN----CLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEE-LPLTAIEKSRSL--- 1152
            :.|.|.   :|.    |.|...:....|.|.. .|.:....:.|..|:: ||.|. |:.:.|
  Rat   141 VQKYHPCFWIDGQYLCCSQTAKNAMGCQILEN-RNGSLKPGSSHRKTKKPLPPTP-EEDQILKKP 203

  Fly  1153 ----PAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSE--------------- 1198
                |.|...|.|.....:::.|..|......      ..:||:...:.|
  Rat   204 LPPEPTAAPISTSELKKVVALYDYMPMNANDL------QLRKGEEYFILEESNLPWWRARDKNGQ 262

  Fly  1199 --FTRGEFLNEK-------SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGD 1254
              :....::.|.       .||.:.:.|.:|| :||..|.:.|.|::||| |:...|::||....
  Rat   263 EGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKS 325

  Fly  1255 T------VKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEK--PVTE 1311
            |      ::||.:....:..:::|.:..|.|:.||:.::..:|.||...|..|..:..|  |.|.
  Rat   326 TGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTA 390

  Fly  1312 GLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMK 1376
            ||.:   ..||||...|.|:::||:||||.|..|.|.....||||.::.|:|...:|:.||::|.
  Rat   391 GLGY---GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMM 452

  Fly  1377 KLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYL 1441
            .|.|.||:|||.|||.:.||:||||.|.:|.||.||:.:..:   .:.|.|::|...:...|.||
  Rat   453 NLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR---FQTQQLLEMCKDVCEAMEYL 514

  Fly  1442 ESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIK 1506
            ||:.::||||||||.||.|..:||::||||:|.:.:|||.:.||::||::|:.||...|||||.|
  Rat   515 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSK 579

  Fly  1507 SDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRP 1571
            ||:|:||:|:.|:.:.|:|||...||:|....:..|.|:.:|.....|:|.||..|||:....||
  Rat   580 SDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERP 644

  Fly  1572 TFETL 1576
            :|:.|
  Rat   645 SFKIL 649

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	29/96 (30%)
		PTKc_Frk_like	1319..1587	CDD:270653	117/258 (45%)
		Pkinase_Tyr	1328..1580	CDD:285015	113/249 (45%)
Btk	NP_001007799.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910