Protein Alignment Src42A and Bmx

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_001102486.1
• Gene: Bmx / 367786
• RGDID: 1565643
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 714
• Identity: 209/714 - (29%)
• Similarity: 326/714 - (45%)
• Gaps: 128/714 - (17%)

  Fly   949 DQSGKSV-QEQGAPKSNKPNKMRRLS----------NILSYSRNSGEDQQETTGKEETKPKRTQA 1002
            :...||: :|....||.:..||..::          ..|||.......:....|..|.|..|...
  Rat     4 NMDSKSILEELLLKKSQQKKKMSPINYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEVKKIRCVE 68

  Fly  1003 KRRIGVTNLLLPLDSEELYTRIIAQQRGLDKEHSQEPEEKC----ASEEQ--------------- 1048
            |     .||......|..|...|..:.||...::...|.:|    |.:::
  Rat    69 K-----VNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGF 128

  Fly  1049 ------MCTRNALTKSSSLDA----ISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKH 1103
                  :|.:.:...:.....    ..|.:|||.....:|..|.|.||..|.:      |:.|..
  Rat   129 FVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERILKIPRAV------PILKMD 187

  Fly  1104 SLDNCLQVVSSTTSRQP-----LRRWSNQTPL-------KCTC-------HPATEELPLTAIEKS 1149
            :        ||:::..|     |::..:..|.       :..|       .|.:||    .|.:|
  Rat   188 A--------SSSSAIPPQYDSHLKKSYDSQPTVNIRYIPREDCPDWWQIRKPKSEE----DIARS 240

  Fly  1150 RSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRK 1214
            ..|             ..:::..||:      |.|....:...|.      ..|.|:...|:...
  Rat   241 NQL-------------ERNIVSHSPS------KMSWGFPESSSSE------EEENLDAYDWFAGN 280

  Fly  1215 IKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLS-----VRD-GDTVKHYRIRQLDEGGFFIAR 1273
            |.|.::| :||..:.:.|||::|:| |:...|::|     |.| ..|||||.:....|...::|.
  Rat   281 ISRSQSE-QLLRQKGKEGAFMVRNS-SQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAE 343

  Fly  1274 RTTFRTLQELVEHYSKDSDGLCVNLCKPCVQTNSFSGVFEIEKPVTEGLSHRTRDQWEIDRTSLK 1338
            ...|.::.:|:.::..:|.|:...|..| |.|.:      .:.||:..|....   ||:.|..:.
  Rat   344 NYCFDSIPKLIHYHQHNSAGMITRLRHP-VSTKA------NKVPVSVALGSGI---WELKREEIA 398

  Fly  1339 FVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE 1403
            .:::|||||||.|..|.|.....||:|.:|.|.|...:|..|||.|.||.|.||::.|.||:.:.
  Rat   399 LLKELGSGQFGVVQLGKWKGQYSVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKY 463

  Fly  1404 PIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVG 1468
            ||||:||.:.:|.||.||:   ..|:.|:...|::|...:..|||:|||..:|||||||||.||.
  Rat   464 PIYIVTEYITNGCLLNYLK---NHGKGLESSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD 525

  Fly  1469 DGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR 1533
            ....||::|||:.|.:.:|:|.:.||.:||:||:|||..:|.|:|.|||||:||||:.|:.:.|:
  Rat   526 SDLSVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGK 590

  Fly  1534 IPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQ 1597
            .||....|:||:.:|..|:|:.:|......:|:||..|||:.|.:||||:.|...:|.....|:
  Rat   591 QPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPLREQDK 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	28/96 (29%)
		PTKc_Frk_like	1328..1596	CDD:270653	117/267 (44%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944	20/130 (15%)
		SH2_Tec_Bmx	269..374	CDD:198262	32/107 (30%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	114/257 (44%)