DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Ptk6

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001102438.1	Gene:	Ptk6 / 366275	RGDID:	1309098	Length:	451	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	180/402 - (44%)
Similarity:	242/402 - (60%)	Gaps:	16/402 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1187 TAKKGKSRRLSE-FTRGEFLNEKS------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHN 1244
            |....:.:.|:| :....:|.||.      |:|..|.|.||..:|...:...|.||||.|:....
  Rat    48 TLLDAEGKALAEGYVPHNYLAEKETVESEPWFFGCISRSEAMHRLQSEDYPKGTFLIRVSQKPGA 112

  Fly  1245 DYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPV 1309
            ||.|||.|.:.|:||||.:...|...:....:|.:|.|||.::...:....:.|...|.:::
  Rat   113 DYVLSVWDAEAVRHYRIWRNSAGRLHLNEVVSFSSLSELVNYHKTHNLSPGLQLSMACWKLK--- 174

  Fly  1310 TEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTL-KSGTMDPKDFLAEAQ 1373
            ||.|.|  .|.||..|......:|||||.||:|:||||.....||:|.: :...:....|.||.|
  Rat   175 TEPLPH--WDDWERPREEFTLCKKLGSGYFGEVFEGLWKGLVRVAVKVISRDNLLHQHTFQAEIQ 237

  Fly  1374 IMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGM 1438
            .||||||..::.||||.|..:|:|||||||..||||:.|:  ....:.|.:..|:|.|:|:|.||
  Rat   238 AMKKLRHKHILSLYAVATAGDPVYIITELMPKGSLLQLLR--DSDEKDLPILELVDFASQVAEGM 300

  Fly  1439 AYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKF 1503
            .|||||||||||||||||||.:.|:.|:.|||||||:|||.|.:| ....|.|||||||.:...:
  Rat   301 CYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARLVKEDIYLSR-DHNVPYKWTAPEALSRGHY 364

  Fly  1504 SIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPM 1568
            ||||||||||:||.|:.:.|::|||||:|.|...:|:.|||||.|..|.|.::::||.||.:||.
  Rat   365 SIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPK 429

  Fly  1569 RRPTFETLQWKL 1580
            :||.|:.|..||
  Rat   430 QRPCFKDLCEKL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	31/90 (34%)
		PTKc_Frk_like	1319..1587	CDD:270653	138/263 (52%)
		Pkinase_Tyr	1328..1580	CDD:285015	132/252 (52%)
Ptk6	NP_001102438.1	SH3_Brk	12..69	CDD:212781	4/20 (20%)
		SH2_PTK6_Brk	75..174	CDD:198221	32/98 (33%)
		PKc_like	184..444	CDD:304357	137/261 (52%)
		STYKc	192..441	CDD:214568	132/251 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920