DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Ack-like

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	128/403 - (31%)
Similarity:	189/403 - (46%)	Gaps:	73/403 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1194 RRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKH 1258
            |||.:|....|.:.   |..||||:     |..|                         |..||.
  Fly    55 RRLRKFYEKHFPHS---YLSKIKRL-----LQAP-------------------------GTMVKR 86

  Fly  1259 YRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTR---DQ 1320
               .:...||..:|                  .||...:.|....     ...|.|..::   ::
  Fly    87 ---EEAPGGGSQVA------------------LDGSSASACSSLA-----AKNGASSPSKVPNNK 125

  Fly  1321 WEIDRTSLKFVRKLGSGQFGDVWEGLWNN---TTPVAIKTLKSGTM--DPKDFLAEAQIMKKLRH 1380
            ..|...|:...::||:|:||.|.:|:|:|   ...||||.|....|  :|.:||.||.||..:.|
  Fly   126 HIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEH 190

  Fly  1381 TKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQN 1445
            ..:::||.|....:.:.::|||....||||.|:....:...|.:.||.:.|.||..||.|||.:.
  Fly   191 ENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKR 255

  Fly  1446 YIHRDLAARNVLVGDGNIVKIADFGLARL--IKEDEYEA--RVGARFPIKWTAPEAANYSKFSIK 1506
            .|||||||||:||...:.|||:||||:|.  :.:|.|:.  .|..:.||.|.|||..||.:|:..
  Fly   256 LIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNA 320

  Fly  1507 SDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVE--HGYRMPQPPNCEPRLYEIMLECWHKDPMR 1569
            ||||:||:.|.|:.:||..|:..:|..::|..::  :..|:.||..|....|.:|::||..|..:
  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAK 385

  Fly  1570 RPTFETLQWKLED 1582
            ||.|..:..:|.|
  Fly   386 RPRFGEIYDQLPD 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	16/90 (18%)
		PTKc_Frk_like	1319..1587	CDD:270653	105/275 (38%)
		Pkinase_Tyr	1328..1580	CDD:285015	101/262 (39%)
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	4/9 (44%)
		STYKc	133..396	CDD:214568	101/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	102/260 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950