DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Btk29A

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	195/558 - (34%)
Similarity:	273/558 - (48%)	Gaps:	98/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1050 CTRNALTKSSSLDAISLSVAI-----------SPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKH 1103
            ||..:|...|||.....|..:           .|...|:|..|....|
  Fly   291 CTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAK----------------- 338

  Fly  1104 SLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHP--ATEELPLTAIEKSRSLPAACSASCSHTCAH 1166
              ||                 |:...|....:|  |.|...| ::||:               |.
  Fly   339 --DN-----------------SHFVKLVVALYPFKAIEGGDL-SLEKN---------------AE 368

  Fly  1167 LSVIDQSP----ATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLP 1227
            ..|||.|.    ......|......:...|.:.|....|.|      ||...:.|..|| .||..
  Fly   369 YEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYE------WYVGDMSRQRAE-SLLKQ 426

  Fly  1228 ENEHGAFLIRDSESRHNDYSLSVR---DGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSK 1289
            .::.|.|::|.|.:: ..|:||:.   ....||||.|:|.....::::.:....|:.:|:.::..
  Fly   427 GDKEGCFVVRKSSTK-GLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRH 490

  Fly  1290 DSDGLCVNL-CKPCVQIEKPV--TEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTT 1351
            :|.||...| ..||   ::||  |.||||   |:|||....|..:.:|||||||.|..|.|..:.
  Fly   491 NSGGLACRLKSSPC---DRPVPPTAGLSH---DKWEIHPMELMLMEELGSGQFGVVRRGKWRGSI 549

  Fly  1352 PVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYL---- 1412
            ..|:|.:|.|||...||:.||::|.||:|..|:|||.||:...||||:||.|||||||.||
  Fly   550 DTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE 614

  Fly  1413 QAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKE 1477
            :.:.|     .|..|:||..|::.||.|||..|||||||||||.|||..|:||:|||||||.:.:
  Fly   615 KTLIG-----NMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLD 674

  Fly  1478 DEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHG 1542
            |:|.:..|.:|||||..||..||::||.|||||::|:|:.|:.|.|::||..:.|.||:.:|:.|
  Fly   675 DQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRG 739

  Fly  1543 YRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL 1580
            ..:.:|.:|...:|::|..||...|..||.|..|..:|
  Fly   740 IILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQL 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	26/94 (28%)
		PTKc_Frk_like	1319..1587	CDD:270653	128/266 (48%)
		Pkinase_Tyr	1328..1580	CDD:285015	123/255 (48%)
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944
		SH3_Tec_like	346..399	CDD:212702	13/68 (19%)
		SH2_Tec_family	403..505	CDD:198188	30/112 (27%)
		PTKc_Tec_like	521..778	CDD:173637	125/262 (48%)
		Pkinase_Tyr	526..777	CDD:285015	123/255 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468350
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950