Protein Alignment Src42A and hop

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_511119.2
• Gene: hop / 32080
• FlyBaseID: FBgn0004864
• Length: 1177
• Species: Drosophila melanogaster
• Alignment Length: 1274
• Identity: 263/1274 - (20%)
• Similarity: 423/1274 - (33%)
• Gaps: 455/1274 - (35%)

  Fly   470 DSTSTLSSMDSGFMEMQNKLDALAAAAAATLIGESTPPLGEAAAPLGEAAPSSAIGEKIDRRNYK 534
            |.::.|:.||....:.:...|..|..:...|.....||      .|.. |.|..:|.||     :
  Fly   171 DKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPP------SLWR-AHSFFVGSKI-----R 223

  Fly   535 ECLTQSRNRRKSYEEFKAMFIEPPAEASKSVTVPPPVVAPA--DDATTASSTVIPLSSISEQENI 597
            |.....:....|.|..|..::...:.           :||.  .:..|.:...:|...::
  Fly   224 EVFRSLKANSLSVERLKWHYVHQVSH-----------LAPTYMTEQFTCTVQYLPNEEVA----- 272

  Fly   598 GSRGVRGKPDCANEFTASTDEM-DTGDGNSDGEKGAAAEVDLTTETTATAKTLVSSSTTEAMRKN 661
                 ||..........||..: .:|..|:           |:|.||.|....:..|..:|.|::
  Fly   273 -----RGSGPIGTSLAHSTSTLASSGSTNT-----------LSTLTTNTNSVALGGSGKKAKRRS 321

  Fly   662 S----DFLSQILDHQFAAKERAKAHKRRTSYEEFK-RLVNEIEPL----ECPNTQPTVSAAVTPT 717
            :    |...::..|.  :.|......|.||....| .||..:|.:    :..:|...:.....|
  Fly   322 TSGGIDVYVRVFPHD--SLEPGLKVARVTSEATLKWILVGAVEGIFMISKINDTSVRLEIVGLP- 383

  Fly   718 TATAAAAASLIKRQNSRQRKSFASYF-------------LPHRHSTKEQKTEKENCSRDPIKPSQ 769
                  ....::.|..::.|||.||.             |.|.:.|                ||.
  Fly   384 ------KGYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRT----------------PSL 426

  Fly   770 EQQLAV-C--------GKLPLHRSNTSDISSSYY----RRNFKIYDKLVYGTI-YDIIQRKNDIY 820
            |:..:: |        ..:.||.:  .|...||.    .|.:.||    |..| ..|:.:|.|
  Fly   427 EELSSLHCHGPIGGAYSLMKLHEN--GDKCGSYIVRECDREYNIY----YIDINTKIMAKKTD-- 483

  Fly   821 QKYDKYMTYGTIYEILHRKTSQSSDPWQRKSLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSS 885
            |:..|..|:..:     ||.||    |:                :.|:.|:
  Fly   484 QERCKTETFRIV-----RKDSQ----WK----------------LSYNNGE-------------- 509

  Fly   886 ATVSTINPHKYGTIYDILQGVKIDAGHVKNKPDQ----KSKPTKPPL----------AKPTRFVV 936
                    |...:::::...::.|:      ||:    .||..||||          ||.|...:
  Fly   510 --------HVLNSLHEVAHIIQADS------PDRYRIPASKYDKPPLLLLLLPKNLKAKKTDLQL 560

  Fly   937 SQVVEPVQIPPTDQSGKSVQEQGAPKSNKPNKMRRLSNILSYSRNS------GEDQQETTGKEET 995
            |:.              .:|.:.....|....::...:.:|.|.:.      |:..|::..|:
  Fly   561 SEA--------------ELQRRNPQIFNPRTDLQWYPDSISLSDDGMMFTMRGDWIQQSPVKD-- 609

  Fly   996 KPKRTQAKRRIGVTNLLLPLDSE----------------------------ELYTRIIAQQR--- 1029
                      :.||..:|..|..                            :.||.::...|
  Fly   610 ----------VSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMVMEYSRYGP 664

  Fly  1030 ---------------------GLDKEHSQEPEEKCASEEQMCTRNALTK----SSSLDAISLSVA 1069
                                 ||.:......:.|.......|:...:||    |..|||
  Fly   665 LNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVLDA------ 723

  Fly  1070 ISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTC 1134
              ..|.|..|||.|.
  Fly   724 --KISDPGYPRPYRE-------------------------------------------------- 736

  Fly  1135 HPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEF 1199
                .:.|...::..|:|.||.:...:...|..:.|.:  ..::|  |..|:|.:
  Fly   737 ----SDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYE--IFSRC--KEDLSTLR---------- 783

  Fly  1200 TRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFL-IRDSESRHNDYSLSVRDG---DTVKHYR 1260
                                 :::||..:|..|..| :.|.:........::.||   |..|.:.
  Fly   784 ---------------------QEQLLRQKNLDGNILKMLDQDICPAPIFETIMDGWSDDETKRFS 827

  Fly  1261 IRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQTNSFSGVFEIEKPVTEGLSHR 1325
            ...:      .:|..|.:.  |::.:|          :..|.:.||.
  Fly   828 HHDI------FSRLNTIKA--EILPNY----------MPPPEIATNG------------------ 856

  Fly  1326 TRDQWEIDRTSLKFV------------------------RKLGSGQFGDVWEG--LWNN----TT 1360
            |.|:..|||:.:.|:                        ..:|.|.:|.|::|  .:|:    ..
  Fly   857 TGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLEFNDKDQPRE 921

  Fly  1361 PVAIKTLKSGTMD-PKDFLAEAQIMKKLRHTKLIQL-YAVCTVEEPIYIITELMKHGSLLEYLQA 1423
            .||||.|  .||. ..||..|..||:.|.|..:::. |   ..|:...||.|.::.||...||:.
  Fly   922 QVAIKML--NTMQVSTDFHREIGIMRTLSHPNIVKFKY---WAEKSHCIIMEYLQSGSFDIYLRF 981

  Fly  1424 IAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLV---GDGNIVKIADFGLARLIK 1485
            .|   .:|....|:..|..||.||.||.....|||||||||:||   |||:.|||:|||||:...
  Fly   982 TA---PNLNNPRLVSFALDIANGMKYLSDMGLIHRDLAARNILVDHNGDGDCVKISDFGLAQFAN 1043

  Fly  1486 ED-EYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIP--YPGMTNAE-VLT 1546
            .| .|.|:.....||:|.:|||.:..:||..|||||:|:.|.|:.:.|..|  .|..|:.| .|.
  Fly  1044 SDGYYYAKSKRDIPIRWYSPEAISTCRFSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLN 1108

  Fly  1547 QVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETL 1585
            :::.|.|:.:|.:|...:|::|..|||..|..||:|.|:
  Fly  1109 RLQSGERLNRPASCPDFIYDLMQLCWHATPRSRPSFATI 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	14/94 (15%)
		PTKc_Frk_like	1328..1596	CDD:270653	105/297 (35%)
hop	NP_511119.2	B41	39..259	CDD:214604	21/110 (19%)
		SH2_Jak_family	420..516	CDD:198177	29/166 (17%)
		PTK_Jak_rpt1	584..836	CDD:270633	50/366 (14%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	100/270 (37%)