DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Lck

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_006238994.1	Gene:	Lck / 313050	RGDID:	2994	Length:	520	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	245/522 - (46%)
Similarity:	325/522 - (62%)	Gaps:	55/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1111 VVSSTTSRQPLRRWSNQTPLKCTCH------PATEELPLTAIEKSR--------SLPAACS---- 1157
            ::....|..|...|.....:...||      .:...||:....:.|        |||.|..
  Rat    11 IMGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKSTLPIRTGSEVRDPLVTYEGSLPPASPLQDN 75

  Fly  1158 ---ASCSHTCAH-----------LSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEF---TRGEFL 1205
               |..|:..:|           |.:::||....|.   .||||.::|    ...|   .:...|
  Rat    76 LVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKA---QSLTTGQEG----FIPFNFVAKANSL 133

  Fly  1206 NEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLD 1265
            ..:.|:|:.:.|.:||::||.|.|.||:||||:|||....:||||||     |:.||||:||.||
  Rat   134 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLD 198

  Fly  1266 EGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKF 1330
            .|||:|:.|.||..|.:||.||:..|||||..|.:|| |.:||....    ..|:||:.|.:||.
  Rat   199 NGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPC-QTQKPQKPW----WEDEWEVPRETLKL 258

  Fly  1331 VRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEP 1395
            |.:||:||||:||.|.:|..|.||:|:||.|:|.|..|||||.:||:|:|.:|::||||.| :||
  Rat   259 VERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVT-QEP 322

  Fly  1396 IYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGD 1460
            ||||||.|::|||:::|:  ...|..|.:..|:|||||||.|||::|.||||||||.|.|:||.|
  Rat   323 IYIITEYMENGSLVDFLK--TPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSD 385

  Fly  1461 GNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRI 1525
            ....|||||||||||:::||.||.||:||||||||||.||..|:||||||||||||||:||:|||
  Rat   386 TLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRI 450

  Fly  1526 PYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSD 1590
            |||||||.||:..:|.||||.:|.||...||.:|:.||.:.|..||||:.|:..|:||:|:.:..
  Rat   451 PYPGMTNPEVIQNLEKGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQ 515

  Fly  1591 YK 1592
            |:
  Rat   516 YQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	51/95 (54%)
		PTKc_Frk_like	1319..1587	CDD:270653	162/267 (61%)
		Pkinase_Tyr	1328..1580	CDD:285015	154/251 (61%)
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938	13/59 (22%)
		SH2_Src_Lck	134..234	CDD:198225	51/99 (52%)
		PTKc_Lck_Blk	248..511	CDD:270652	160/265 (60%)
		Pkinase_Tyr	256..505	CDD:285015	154/251 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920