DRSC/TRiP Functional Genomics Resources

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Protein Alignment Src42A and Abl1

DIOPT Version :9

Sequence 1:NP_610191.2 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1597 Species:Drosophila melanogaster
Sequence 2:NP_001094320.1 Gene:Abl1 / 311860 RGDID:1584969 Length:1143 Species:Rattus norvegicus


Alignment Length:439 Identity:188/439 - (42%)
Similarity:261/439 - (59%) Gaps:29/439 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly  1181 GKTSLTTAKKGKSRRLSEFTRGEF----------------------LNEKSWYFRKIKRIEAEKK 1223
            |..:|:..|..|.|.|.....||:                      |.:.|||...:.|..||  
  Rat    95 GDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAE-- 157

  Fly  1224 LLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288
            .||....:|:||:|:|||.....|:|:|....|.||||....:|..:::..:.|.||.|||.|:|
  Rat   158 YLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHS 222

  Fly  1289 KDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNN-TTP 1352
            ..:|||...|..|..:..||...|:| ...|:||::||.:....|||.||:|:|:||:|.. :..
  Rat   223 TVADGLITTLHYPAPKRNKPTIYGVS-PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLT 286

  Fly  1353 VAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAG 1417
            ||:||||..||:.::||.||.:||:::|..|:||..|||.|.|.|||||.|.:|:||:||:..  
  Rat   287 VAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC-- 349

  Fly  1418 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEA 1482
            ..:.:....|:.||.||::.|.|||.:|:|||||||||.|||:.::||:|||||:||:..|.|.|
  Rat   350 NRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTA 414

  Fly  1483 RVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQ 1547
            ..||:|||||||||:..|:|||||||||:||:||.|:.|||..||||:..::|...:|..|||.:
  Rat   415 HAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 479

  Fly  1548 PPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLED-FYTSDQSDYKEAQ 1595
            |..|..::||:|..||..:|..||:|..:....|. |..|..||..|.:
  Rat   480 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKE 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Src42ANP_610191.2 SH2_Src_Src42 1210..1301 CDD:198233 35/90 (39%)
PTKc_Frk_like 1319..1587 CDD:270653 134/269 (50%)
Pkinase_Tyr 1328..1580 CDD:285015 127/252 (50%)
Abl1NP_001094320.1 SH3_Abl 84..137 CDD:212784 8/41 (20%)
SH2_ABL 142..235 CDD:198189 36/94 (38%)
PTKc_Abl 254..516 CDD:270645 132/263 (50%)
Pkinase_Tyr 261..512 CDD:285015 127/252 (50%)
FABD 1019..1143 CDD:197885
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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