DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Txk

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001019426.1	Gene:	Txk / 305311	RGDID:	1306481	Length:	526	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	162/387 - (41%)
Similarity:	242/387 - (62%)	Gaps:	27/387 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRH-NDYSLSV------RDGDTVKHYRIR 1262
            |....||.:.|.|.:.| :||..|.:.|||::||  ||| ..|::||      ....::|||:|:
  Rat   144 LETYEWYHKNITRDQTE-RLLRQEAKEGAFIVRD--SRHLGSYTISVFTRARRHTQSSIKHYQIK 205

  Fly  1263 QLDEGGFFIARRTTFRTLQELVEHYSKDSDGLC------VNLCKPCVQIEKPVTEGLSHRTRDQW 1321
            :.|.|.:::..|..|.::.||::::..::.||.      |.|...|:    |.|.|.|:   ::|
  Rat   206 KNDSGQWYVTERHLFPSVPELIQYHQYNAAGLMSRLRYPVGLLGSCL----PATSGFSY---EKW 263

  Fly  1322 EIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQL 1386
            |||.:.|.||:::||||||.|:.|.|.....||||.:..|:|..:||:.||::|.||.|::|:||
  Rat   264 EIDPSELTFVKEIGSGQFGVVYLGEWRARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQL 328

  Fly  1387 YAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDL 1451
            |.||..::|:||:||.|::|.||:||:...||   |....|:.|...|..||||||...||||||
  Rat   329 YGVCIQQKPLYIVTEFMENGCLLDYLRERKGK---LPKALLLSMCQDICEGMAYLEKSCYIHRDL 390

  Fly  1452 AARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILL 1516
            ||||.||....:|||:|||:||.:.:|||.:..||:||:||:.||..:::|:|.||||||||:|:
  Rat   391 AARNCLVSSACVVKISDFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLM 455

  Fly  1517 TELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTF-ETLQ 1577
            .|:.|.|::|:...:|.:|:..:..|:|:.:|......:|.:|..|||:.|..|||| |.||
  Rat   456 WEVFTEGKMPFENKSNLQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQ 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	33/103 (32%)
		PTKc_Frk_like	1319..1587	CDD:270653	123/260 (47%)
		Pkinase_Tyr	1328..1580	CDD:285015	119/251 (47%)
Txk	NP_001019426.1	SH3_TXK	84..138	CDD:212840
		SH2_Tec_Txk	142..247	CDD:198261	33/105 (31%)
		PKc_like	265..520	CDD:304357	121/256 (47%)
		Pkinase_Tyr	270..519	CDD:285015	119/251 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910