Protein Alignment Src42A and Tnk1

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: XP_006246766.1
• Gene: Tnk1 / 303247
• RGDID: 1310113
• Length: 740
• Species: Rattus norvegicus
• Alignment Length: 565
• Identity: 145/565 - (25%)
• Similarity: 211/565 - (37%)
• Gaps: 168/565 - (29%)

  Fly  1072 PASSPSPPR----------------PRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQP 1120
            |.|...||:                ||..|.:.|.....:||.:.::....:.|...||..
  Rat    22 PVSRTRPPQPGVPPFLGFIARHLGGPRSCLFRFRQAIHLKQTAVLRRGLTPDMLPEASSLW---- 82

  Fly  1121 LRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSL 1185
            |.|......|.....|..|||.:|..|                  |...:..........|:.:
  Rat    83 LLRLLRDVQLAQFYRPILEELNVTRPE------------------HFDFVRPEDLDNLGMGRPA- 128

  Fly  1186 TTAKKGKSRRLSE----FTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDY 1246
                   .|||:|    :..|  :..|:|.::.:.....|:|.:.|                  |
  Rat   129 -------QRRLTEALKRYRSG--VKSKNWVYKILGGFAPEQKEIPP------------------Y 166

  Fly  1247 SLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQTNSFSGV 1311
            |      |::.|.   ...|||.                               .|:
  Rat   167 S------DSLPHL---HEPEGGL-------------------------------KCL-------- 183

  Fly  1312 FEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLW----NNTTPVAIKTLKSGTM 1372
                  :.||         .:.|..|     ||||.||.|.:|||    ..:.|||:|:|:.|..
  Rat   184 ------IPEG---------AVCRGEL-----LGSGCFGVVHQGLWTLPGGQSIPVAVKSLRVGPE 228

  Fly  1373 DPK-----DFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLK 1432
            .|.     |||.|..:|.||.|..:::|:.: .:.:|:.::.||...|||...|.|.|.. ..|.
  Rat   229 GPMGTELGDFLREVSVMMKLEHPHVLRLHGL-VLGQPLQMVMELAPLGSLHARLTAPAPM-PPLP 291

  Fly  1433 MQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGAR- 1496
            :..|.....|:|..||||.|...:|||||.||:|:.....:|:|||||.|.:.        |||
  Rat   292 VTLLCLFLRQLAGAMAYLGSCGLVHRDLATRNLLLASPRKIKVADFGLVRPLG--------GARG 348

  Fly  1497 ---------FPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHG- 1551
                     .|..|.|||:.....||..||||.||:.|.|:.:.|..|:.|:....:|.::|..
  Rat   349 RYVMGGPRPIPYAWCAPESLRQGAFSAASDVWMFGVTLWEMFSGGEEPWAGVPPYLILQRLEKDR 413

  Fly  1552 YRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSD 1596
            .|:|:|..|...||.:.|.||...|..||||..|:..|::.:.|:
  Rat   414 ARLPKPALCSRALYSLALRCWAPHPADRPTFSNLEGLLQEAWLSE 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	11/90 (12%)
		PTKc_Frk_like	1328..1596	CDD:270653	100/287 (35%)
Tnk1	XP_006246766.1	SAM_TNK-like	89..140	CDD:188938	13/76 (17%)
		Protein Kinases, catalytic domain	193..453	CDD:473864	99/274 (36%)
		SH3	<468..509	CDD:473055
		UBA_like_SF	668..711	CDD:473871
		UBA_like_SF	698..737	CDD:473871