Protein Alignment Src42A and Zap70

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: XP_006244823.1
• Gene: Zap70 / 301348
• RGDID: 3983
• Length: 638
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 181/642 - (28%)
• Similarity: 269/642 - (41%)
• Gaps: 150/642 - (23%)

  Fly  1077 SPPRPRRS-LKQHRCLQQHQQTP----------------LAKKH-----------SLDNCLQ--- 1110
            ||.:|.|| |....||.|....|                .|::|           .|..||:
  Rat     4 SPGKPGRSLLPSMACLVQGPAMPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLG 68

  Fly  1111 --VVSSTTSRQ----PLRRWSNQTPL----KCTCHPATEELPLTAIEKSRSLPAACSASCSH--- 1162
              |:|.....:    |:.|..|.|..    |..|.||  ||.....:....||......|:.
  Rat    69 GYVLSLVHDVRFHHFPIERQLNGTYAIAGGKAHCGPA--ELCQFYSQDPDGLPCNLRKPCNRPPG 131

  Fly  1163 ----------------------------TCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEF 1199
                                        .....::|.|:|...|...    |||.:
  Rat   132 LEPQPGVFDCLRDAMVRDYVRQTWKLEGDALEQAIISQAPQVEKLIA----TTAHE--------- 183

  Fly  1200 TRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQL 1264
                   ...||...:.|.|||:||...:...|.||:|..:.: ..|:||:..|.||.||.|.|.
  Rat   184 -------RMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQ-GTYALSLVYGKTVYHYLISQD 240

  Fly  1265 DEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPC--------------------------- 1302
            ..|.:.|...|.|.||.:|||:....:|||...|.:.|
  Rat   241 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFTQPHRR 305

  Fly  1303 VQTNSFSGV----FEIEKPVTEGLSHRTRDQWEIDRTSLK----FVRK---------LGSGQFGD 1350
            :.|.:..|.    ..::||....:.....:....|...||    |:::         ||.|.||.
  Rat   306 IDTLNSDGYTPEPARLDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGS 370

  Fly  1351 VWEGLW---NNTTPVAIKTLKSGT--MDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITE 1410
            |.:|::   .....||||.||..|  .|..:.:.|||||.:|.:..:::|..||.. |.:.::.|
  Rat   371 VRQGVYRMRKKQIDVAIKVLKQSTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVME 434

  Fly  1411 LMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKI 1475
            :...|.|.::|   .||...:.:..:.::..|:|.||.|||.:|::||||||||||:.:.:..||
  Rat   435 MAGGGPLHKFL---IGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKI 496

  Fly  1476 ADFGLARLIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPG 1538
            :||||::.:..|:  |.||...::|:||.|||..|:.|||.:|||||:|:.:.|..:||:.||..
  Rat   497 SDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKK 561

  Fly  1539 MTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTS 1595
            |...|||..::.|.||..||.|.|.:|.:|.:||......||.|..::.::..:|.|
  Rat   562 MKGPEVLDFIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFVAVEQRMRTYYYS 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	35/90 (39%)
		PTKc_Frk_like	1328..1596	CDD:270653	104/288 (36%)
Zap70	XP_006244823.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191	20/104 (19%)
		SH2	176..280	CDD:472789	39/124 (31%)
		PTKc_Zap-70	352..620	CDD:270686	100/271 (37%)