DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Srms

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001011961.1	Gene:	Srms / 296472	RGDID:	1306602	Length:	507	Species:	Rattus norvegicus

Alignment Length:	375	Identity:	183/375 - (48%)
Similarity:	242/375 - (64%)	Gaps:	10/375 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1206 NEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFF 1270
            :::.|||..|.|.:|::.||.|.|..||||||.|||....||||||....|.||||.....||.:
  Rat   131 SDQPWYFNGISRTQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRICMAPSGGLY 195

  Fly  1271 IARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLG 1335
            :.....|.:|..|:.:|..:...:...|.:|||. :.|:.:       |:||..|:.....||||
  Rat   196 LQEGRLFPSLDALLAYYKTNWKLIQNPLLQPCVP-QMPLAQ-------DEWERPRSEFVLRRKLG 252

  Fly  1336 SGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIIT 1400
            .|.||:||||||..:||||:|.:||..|...|...|.:.:|.|||.:||:|:|:|::.||:||:|
  Rat   253 EGFFGEVWEGLWLGSTPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVT 317

  Fly  1401 ELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVK 1465
            |||..|:|..||.  :.:|::|.:..|:..|.|:|.||:|||.:..:|||||||||||||....|
  Rat   318 ELMGKGNLQVYLG--SPEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCK 380

  Fly  1466 IADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGM 1530
            :||||||||:|:|.|....|::.|:||||||||||..||.|||||||||||.|:.|||:.||.||
  Rat   381 VADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGM 445

  Fly  1531 TNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL 1580
            ||.|.|.|:..|||:|:|..|...:|.:|:|||...|..||||.||:.||
  Rat   446 TNHETLQQISRGYRLPRPAVCPAEVYMLMVECWKGSPEERPTFATLREKL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	37/90 (41%)
		PTKc_Frk_like	1319..1587	CDD:270653	142/262 (54%)
		Pkinase_Tyr	1328..1580	CDD:285015	136/251 (54%)
Srms	NP_001011961.1	SH3	70..124	CDD:302595
		SH2	134..212	CDD:301589	35/77 (45%)
		PTKc_Srm_Brk	238..498	CDD:133248	141/260 (54%)
		Pkinase_Tyr	245..495	CDD:285015	136/251 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920