DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and FYN

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	419	Identity:	243/419 - (57%)
Similarity:	309/419 - (73%)	Gaps:	14/419 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1184 SLTTAKKG--KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDY 1246
            ||||.:.|  .|..::..   :.:..:.|||.|:.|.:||::||...|..|.||||:||:....|
Human   124 SLTTGETGYIPSNYVAPV---DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAY 185

  Fly  1247 SLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIE 1306
            |||:||     ||.||||:||:||.||::|..|..|.|||:||:|||:.:.|||..|..||.:..
Human   186 SLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGM 250

  Fly  1307 KPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371
            ..:|: ||.:|:|.|||.|.||:.:::||:||||:||.|.||..|.|||||||.|||.|:.||.|
Human   251 PRLTD-LSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEE 314

  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436
            |||||||:|.||:|||||.: ||||||:||.|..||||::|:  .|:||:||:..|:|||||:||
Human   315 AQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLK--DGEGRALKLPNLVDMAAQVAA 376

  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501
            ||||:|..|||||||.:.|:|||:|.|.|||||||||||:::||.||.||:|||||||||||.|.
Human   377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 441

  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566
            :|:|||||||||||||||||.||:|||||.|.|||.|||.|||||.|.:|...|:|:|:.||.||
Human   442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKD 506

  Fly  1567 PMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595
            |..|||||.||..|||::|:.:..|:..:
Human   507 PEERPTFEYLQSFLEDYFTATEPQYQPGE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	50/95 (53%)
		PTKc_Frk_like	1319..1587	CDD:270653	180/267 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	170/251 (68%)
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939	6/15 (40%)
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281	50/99 (51%)
		PTKc_Fyn	261..534	CDD:270655	181/275 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.880