DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Fyn

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_006256584.1	Gene:	Fyn / 25150	RGDID:	2641	Length:	575	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	243/419 - (57%)
Similarity:	309/419 - (73%)	Gaps:	14/419 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1184 SLTTAKKG--KSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDY 1246
            ||||.:.|  .|..::..   :.:..:.|||.|:.|.:||::||...|..|.||||:||:....|
  Rat   162 SLTTGETGYIPSNYVAPV---DSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAY 223

  Fly  1247 SLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIE 1306
            |||:||     ||.||||:||:||.||::|..|..|.|||:||:|||:.:.|||..|..||.:..
  Rat   224 SLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGM 288

  Fly  1307 KPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371
            ..:|: ||.:|:|.|||.|.||:.:::||:||||:||.|.||..|.|||||||.|||.|:.||.|
  Rat   289 PRLTD-LSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEE 352

  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436
            |||||||:|.||:|||||.: ||||||:||.|..||||::|:  .|:||:||:..|:|||||:||
  Rat   353 AQIMKKLKHDKLVQLYAVVS-EEPIYIVTEYMNKGSLLDFLK--DGEGRALKLPNLVDMAAQVAA 414

  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501
            ||||:|..|||||||.:.|:|||:|.|.|||||||||||:::||.||.||:|||||||||||.|.
  Rat   415 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 479

  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566
            :|:|||||||||||||||||.||:|||||.|.|||.|||.|||||.|.:|...|:|:|:.||.||
  Rat   480 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKD 544

  Fly  1567 PMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595
            |..|||||.||..|||::|:.:..|:..:
  Rat   545 PEERPTFEYLQGFLEDYFTATEPQYQPGE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	50/95 (53%)
		PTKc_Frk_like	1319..1587	CDD:270653	180/267 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	170/251 (68%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939	6/15 (40%)
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	50/99 (51%)
		PTKc_Fyn	299..572	CDD:270655	181/275 (66%)
		Pkinase_Tyr	309..558	CDD:285015	170/251 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I8819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930