DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and FRK

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_002022.1	Gene:	FRK / 2444	HGNCID:	3955	Length:	505	Species:	Homo sapiens

Alignment Length:	507	Identity:	274/507 - (54%)
Similarity:	345/507 - (68%)	Gaps:	41/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly  1122 RRWSNQTP-LKCTCHPATEELPLTAIEKSRSLPAACS-ASCSHTCAHLSVIDQSPATTK------ 1178
            |.|....| |.|.   :||....|.||...:|   || .|..|....:::.|....|.:
Human     7 RLWEYLEPYLPCL---STEADKSTVIENPGAL---CSPQSQRHGHYFVALFDYQARTAEDLSFRA 65

  Fly  1179 --------------CFGKTSLTTAKKGKSRRLSEFTRGEFLNE------KSWYFRKIKRIEAEKK 1223
                          .|.: .|...:.|.|::|..:....::.|      :.|:|..|.|.:|||:
Human    66 GDKLQVLDTLHEGWWFAR-HLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQ 129

  Fly  1224 LLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYS 1288
            ||..||:.|:||||:|||:..::||||.||..||||||::|||||||:.||..|.||.|.|.||:
Human   130 LLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYT 194

  Fly  1289 KDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPV 1353
            |.||||||.|.|||::|:.|....||::|.|||||||.|::.:::|||||||:||||||||||||
Human   195 KTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPV 259

  Fly  1354 AIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGK 1418
            |:||||.|:|||.|||.||||||.|||.||||||||||:|:|||||||||:||||.||||...|.
Human   260 AVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGS 324

  Fly  1419 GRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIK---EDEY 1480
            ...|..|  :|||||:|:|||||||:|||||||||||||||:.||.|:|||||||:.|   ||.|
Human   325 KIHLTQQ--VDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIY 387

  Fly  1481 EARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRM 1545
            |:|...:.|:|||||||...:|||||||||||||||.|::|||::||.|||.|:|:..:...||:
Human   388 ESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRL 452

  Fly  1546 PQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEAQAY 1597
            |||.||..:.|.||||||:.:|..|||||||:|||||::.:| |.|.:|..:
Human   453 PQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETD-SSYSDANNF 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	55/90 (61%)
		PTKc_Frk_like	1319..1587	CDD:270653	184/270 (68%)
		Pkinase_Tyr	1328..1580	CDD:285015	172/254 (68%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	7/57 (12%)
		SH2_Src_Frk	112..207	CDD:199831	55/94 (59%)
		PTKc_Frk_like	225..494	CDD:270653	184/270 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	589	1.000	Inparanoid score	I994
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto88993
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.950