Protein Alignment Src42A and FGR

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001036194.1
• Gene: FGR / 2268
• HGNCID: 3697
• Length: 529
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 239/435 - (54%)
• Similarity: 295/435 - (67%)
• Gaps: 36/435 - (8%)

  Fly  1187 TAKKGKSRRLSEFTRGEFLNEKS------------------------WYFRKIKRIEAEKKLLLP 1227
            |..||:...:...|.|::...:|                        |||.||.|.:||::||.|
Human    97 TFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSP 161

  Fly  1228 ENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHY 1287
            .|..||||||:||:....||||:||     ||.||||:||:||.||::|..|..|.::||||:||
Human   162 GNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHY 226

  Fly  1288 SKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTP 1352
            .:.:||||..|..||. |.||.|.||:   :|.|||.|:|:...|:||:|.|||||.|.||.:|.
Human   227 MEVNDGLCNLLIAPCT-IMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287

  Fly  1353 VAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAG 1417
            ||:||||.|||.||.||.|||:||.|||.||:|||||.: ||||||:||.|.|||||::|:  ..
Human   288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLK--NP 349

  Fly  1418 KGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEA 1482
            :|:.|::..|:|||||:|.||||:|..|||||||.|.|:|||:....||||||||||||:|||..
Human   350 EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNP 414

  Fly  1483 RVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQ 1547
            ..|::|||||||||||.:.:|:|||||||||||||||:|.||||||||...|||.|||.||.||.
Human   415 CQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPC 479

  Fly  1548 PPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592
            ||.|...|||.|.:.|..||..|||||.||..|||::||.:..|:
Human   480 PPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQ 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	52/95 (55%)
		PTKc_Frk_like	1319..1587	CDD:270653	171/267 (64%)
		Pkinase_Tyr	1328..1580	CDD:285015	161/251 (64%)
FGR	NP_001036194.1	SH3	80..137	CDD:327375	6/39 (15%)
		SH2_Src_Fgr	140..240	CDD:198230	52/99 (53%)
		PKc_like	267..514	CDD:328722	162/249 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.930