Protein Alignment Src42A and Yes1

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_001192061.1
• Gene: Yes1 / 22612
• MGIID: 99147
• Length: 541
• Species: Mus musculus
• Alignment Length: 550
• Identity: 264/550 - (48%)
• Similarity: 337/550 - (61%)
• Gaps: 57/550 - (10%)

  Fly  1090 CLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPAT--EELPLTAIEKSRSL 1152
            |::..:....|.|::.:|..:.||.:.|...:.. :...|...|...:.  ..|.:|....|..:
Mouse     3 CIKSKENKSPAIKYTPENLTEPVSPSASHYGVEH-ATVAPTSSTKGASVNFNSLSMTPFGGSSGV 66

  Fly  1153 PAACSASCSHTCAHLSVIDQSPATTKCFGKT---------SLTTA----KKGKSRRLSEFTRGEF 1204
            .....||.|     .||:..|..|....|.|         :.||.    |||:..::...|.|::
Mouse    67 TPFGGASSS-----FSVVSSSYPTGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDW 126

  Fly  1205 LNEKS------------------------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHND 1245
            ...:|                        |||.|:.|.:||:.||.|.|:.|.||:|:||:....
Mouse   127 WEARSIATGKSGYIPSNYVVPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGA 191

  Fly  1246 YSLSVRD-----GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQI 1305
            ||||:||     ||.||||:||:||.||::|..|..|.|||:||:||::.:||||..|...|..:
Mouse   192 YSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV 256

  Fly  1306 EKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLA 1370
             ||.|:||:   :|.|||.|.||:...|||.|.||:||.|.||.||.|||||||.|||.|:.||.
Mouse   257 -KPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQ 317

  Fly  1371 EAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIA 1435
            ||||||||||.||:.||||.: ||||||:||.|..||||::|:  .|.|:.||:..|:|||||||
Mouse   318 EAQIMKKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLK--EGDGKYLKLPQLVDMAAQIA 379

  Fly  1436 AGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANY 1500
            .||||:|..|||||||.|.|:|||:..|.|||||||||||:::||.||.||:|||||||||||.|
Mouse   380 DGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 444

  Fly  1501 SKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHK 1565
            .:|:|||||||||||.|||||.||:|||||.|.|||.|||.|||||.|..|...|:|:|..||.|
Mouse   445 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKK 509

  Fly  1566 DPMRRPTFETLQWKLEDFYTSDQSDYKEAQ 1595
            ||..|||||.:|..|||::|:.:..|:..:
Mouse   510 DPDERPTFEYIQSFLEDYFTATEPQYQPGE 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	50/95 (53%)
		PTKc_Frk_like	1319..1587	CDD:270653	178/267 (67%)
		Pkinase_Tyr	1328..1580	CDD:285015	168/251 (67%)
Yes1	NP_001192061.1	SH3_Yes	92..149	CDD:212940	9/56 (16%)
		SH2_Src_family	152..251	CDD:199827	50/98 (51%)
		PTKc_Yes	262..540	CDD:270654	181/283 (64%)
		Pkinase_Tyr	275..524	CDD:285015	168/251 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9017
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960