DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Srms

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_035611.3	Gene:	Srms / 20811	MGIID:	101865	Length:	507	Species:	Mus musculus

Alignment Length:	376	Identity:	181/376 - (48%)
Similarity:	240/376 - (63%)	Gaps:	12/376 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly  1206 NEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFF 1270
            :::.|||..|.|.:|::.||.|.|..||||||.|||....||||||....|.||||.....|..:
Mouse   131 SDQPWYFSGISRAQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRICMAPSGSLY 195

  Fly  1271 IARRTTFRTLQELVEHYSKDSDGLCVNLCKPCV-QIEKPVTEGLSHRTRDQWEIDRTSLKFVRKL 1334
            :.....|.:|..|:.:|..:...:...|.:||: ||  |:.:       |:||..|:.....|||
Mouse   196 LQEGQLFPSLDALLAYYKTNWKLIQNPLLQPCIPQI--PLVQ-------DEWERPRSEFVLRRKL 251

  Fly  1335 GSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYII 1399
            |.|.||:||||||..:.|||:|.:||..|...|...|.:.:|.|||.:||:|:|:|::.||:||:
Mouse   252 GEGFFGEVWEGLWLGSIPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIV 316

  Fly  1400 TELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIV 1464
            ||||..|:|..||.  :.:|::|.:..|:..|.|:|.||:|||.:..:|||||||||||||....
Mouse   317 TELMGKGNLQVYLG--SSEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTC 379

  Fly  1465 KIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPG 1529
            |:||||||||:|:|.|....|::.|:||||||||||..||.|||||||||||.|:.|||:.||.|
Mouse   380 KVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEG 444

  Fly  1530 MTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKL 1580
            |||.|.|.|:..|||:|:|..|...:|.:|:|||...|..||||..|:.||
Mouse   445 MTNHETLQQISRGYRLPRPAVCPAEVYVLMVECWKGSPEERPTFAILREKL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	36/90 (40%)
		PTKc_Frk_like	1319..1587	CDD:270653	140/262 (53%)
		Pkinase_Tyr	1328..1580	CDD:285015	134/251 (53%)
Srms	NP_035611.3	SH3	70..124	CDD:302595
		SH2_Srm	134..212	CDD:198223	34/77 (44%)
		PTKc_Srm_Brk	238..498	CDD:133248	139/260 (53%)
		STYKc	246..495	CDD:214568	134/250 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920