Protein Alignment Src42A and R11E3.1

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_500644.2
• Gene: R11E3.1 / 187810
• WormBaseID: WBGene00020003
• Length: 549
• Species: Caenorhabditis elegans
• Alignment Length: 499
• Identity: 132/499 - (26%)
• Similarity: 224/499 - (44%)
• Gaps: 109/499 - (21%)

  Fly  1182 KTSLTTA--KKGKSRRLSEFT--RGEFLNEKSWYFRK--IKRIEAEKKLLLPENEHGAFLIRDSE 1240
            :..||||  :||..::..:.:  :.|....||.|..|  ::..|..|.|......|| ||.||
 Worm    27 RPDLTTASEEKGSEKKDEKGSDRKDESATSKSVYVEKDVVEDEELYKSLQAMPFYHG-FLPRD-- 88

  Fly  1241 SRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCK----- 1300
                |..:.:|             :||.:.| |.:...|.:|......:|   :.:::|.
 Worm    89 ----DLGVIIR-------------NEGDYLI-RVSEITTKKEGTTGIKRD---IILSVCSSERGG 132

  Fly  1301 -PCVQTNS----------------------FSGVFEIEK---PVTEGL--------SHRTRDQ-- 1329
             ...|||:                      |.|.|.|:.   |..|.|        :..|::.
 Worm   133 TETEQTNTKSDAKSELNLGERKMRNMVIRRFDGKFGIKGNLFPTIEALLANYHVTNALETKENRF 197

  Fly  1330 ---------WEIDRTSLKFVRKLGSGQFGDVWEGLW---NNTTPVAIKTLKSGTMDP---KDFLA 1379
                     ||...:::|...|||.|.:|:|.:|:.   |....||:|.:|.|.::.   ::.:.
 Worm   198 LKTPIDLQVWENRHSAVKLGDKLGEGAYGEVRKGVLHRKNKKLDVAVKLMKGGELNKMKIREMMN 262

  Fly  1380 EAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIA 1444
            ||::|:..:|..:::.:.|..||:|:||:.||:..|:|..|||    |.:...:: |:.|....|
 Worm   263 EARLMRNFKHKNIVRFFGVAVVEQPLYILLELVNGGALNTYLQ----KNKVSDLE-LMRMCLGAA 322

  Fly  1445 AGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANY 1509
            .|:.||.:.:.||||:||||.|..:..:||::||||:  :..::|:.....:.||||.|||....
 Worm   323 QGLQYLHANHCIHRDIAARNCLYSNDKVVKLSDFGLS--VVGNQYKLCAAQKLPIKWLAPETITT 385

  Fly  1510 SKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLE-CWH 1573
            ..|:.|:||:|:|::..|:.:.|..|:.|:||......|.:|..:..|.:|..:....:.| .:.
 Worm   386 RFFTPKTDVYSYGVMCFEIFSNGAEPWEGVTNTVTKNNVVNGINLVIPESCPEKFRSFVHEKIFV 450

  Fly  1574 KDPMRRPTFETLQWKLE----DFY-----------TSDQSDYKE 1602
            .||.||...:.:...:|    |.:           .||:|||.:
 Worm   451 VDPKRRVVMDDVSRFIEPIINDMHNAAAVSTMLNLASDKSDYNQ 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	21/98 (21%)
		PTKc_Frk_like	1328..1596	CDD:270653	86/300 (29%)
R11E3.1	NP_500644.2	SH2_Fps_family	73..191	CDD:198224	28/141 (20%)
		PTKc	218..467	CDD:270623	81/255 (32%)