Protein Alignment Src42A and R05H5.4

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_496201.1
• Gene: R05H5.4 / 174581
• WormBaseID: WBGene00011039
• Length: 414
• Species: Caenorhabditis elegans
• Alignment Length: 388
• Identity: 114/388 - (29%)
• Similarity: 190/388 - (48%)
• Gaps: 57/388 - (14%)

  Fly  1231 HGAFLIRDSESRHNDYSLSVRDGD---TVKHYRIRQLD--EGGFFIA-------RRTTFRTLQEL 1283
            |||.:..|::      .|.|.:||   |:|    :|||  :...|:|       ||...:...:.
 Worm    18 HGALMNIDAD------QLLVNEGDFMVTMK----KQLDINKLQLFLAVRLKKGIRRYEIKRTSKT 72

  Fly  1284 VEHYSKDSDGL--CVNLCKPCVQTNSFSGVFEI--EKPVTEGLSHRTRDQWEIDRTSLKFVRKLG 1344
            .:...|.|..:  .:|:.|        :...||  ||.|.:...  .:.::::....:.|.:|:|
 Worm    73 AKIGGKTSQNIVKLINMLK--------ADPIEIRGEKVVLKRAI--PKGKFQLMHKDVIFQKKIG 127

  Fly  1345 SGQFGDVWEG-LWNNTTPVAIKTLKSGTMDPK--------DFLAEAQIMKKLRHTKLIQLYAVCT 1400
            :|.:|.|:.| |......:|:|.|     ||:        :.:.||::|:...|..:::.:....
 Worm   128 AGAYGTVYRGKLVKTDEVIAVKKL-----DPEGADEDGLAEMMKEARVMQLYDHPNIVKFHGFIL 187

  Fly  1401 VEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNV 1465
            .:.|..::.|....|::.:.|:   .||..:|:.|.:......|.||.||..:|.||||:|:||.
 Worm   188 DDLPYLLVLEYCNGGAVEDRLR---DKGEKIKVPTRVKYTYMAACGMDYLHKKNCIHRDIASRNC 249

  Fly  1466 LVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELV- 1529
            |:..| :||:||||:.|  .:..|:..:.....|:|.|||..:..:....:||::|||::.|..
 Worm   250 LIHKG-VVKMADFGMCR--AQSVYKVDLKKPCNIRWLAPEVWDNGETRFNTDVYAFGIMMWEFFE 311

  Fly  1530 TYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDF 1592
            |..:.||..|..|:|..:...|||:|.||:...|:.|||.|||..|..:|||.|.|:.|||:|
 Worm   312 TPFKSPYVEMKAAQVKRKTRAGYRLPPPPSMPSRMVEIMSECWQVDAEKRPTAEELKEKLEEF 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	20/83 (24%)
		PTKc_Frk_like	1328..1596	CDD:270653	88/275 (32%)
R05H5.4	NP_496201.1	SH2_Fps_family	9..97	CDD:198224	21/96 (22%)
		TyrKc	120..363	CDD:197581	80/253 (32%)