DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and src-2

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_493502.1	Gene:	src-2 / 173296	WormBaseID:	WBGene00005078	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	275/511 - (53%)
Similarity:	345/511 - (67%)	Gaps:	57/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 SSTTSRQPLRRWSNQTPLKCTCHPATEELPLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATT 1177
            |||..|:.|              |:...:|        |:....::|..:|......|.||....
Worm    21 SSTLGRESL--------------PSHPRIP--------SIGPIAASSSGNTIDKNQNISQSANFV 63

  Fly  1178 KCFGKTSLT----TAKKGKSRRLSEFTRGEF-------------------LNEKS-----WYFRK 1214
            ..|...:.|    :.||.....:...|:|::                   ..|||     |||.|
Worm    64 ALFQYDARTDDDLSFKKDDILEILNDTQGDWWFARHKATGRTGYIPSNYVAREKSIESQPWYFGK 128

  Fly  1215 IKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRT 1279
            ::||:|||.||...|||||||:||||||.:|.|||||:.|:||||||||||.||:|||||..|.|
Worm   129 MRRIDAEKCLLHTLNEHGAFLVRDSESRQHDLSLSVRENDSVKHYRIRQLDHGGYFIARRRPFAT 193

  Fly  1280 LQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWE 1344
            |.:|:.||.:::|||||||..||.:.|.|.|...::  .||||:||.|::.:|::|:||||:|||
Worm   194 LHDLIAHYQREADGLCVNLGAPCAKSEAPQTTTFTY--DDQWEVDRRSVRLIRQIGAGQFGEVWE 256

  Fly  1345 GLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLL 1409
            |.||...|||:|.||:||.||.||||||||||||||.||:.||||||.:|||.|:||||:. :||
Worm   257 GRWNVNVPVAVKKLKAGTADPTDFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQE-NLL 320

  Fly  1410 EYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLAR- 1473
            .:||.   :||..:|..|::::||:||||||||..|:|||||||||:|:.:...||||||||||
Worm   321 TFLQR---RGRQCQMPQLVEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARI 382

  Fly  1474 LIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQ 1538
            |:||:|||||.||||||||||||||||::|:.|||||||||||||:||:||:|||||||||||.|
Worm   383 LMKENEYEARTGARFPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQ 447

  Fly  1539 VEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYKEA 1594
            |:.|||||.|..|...||:||.:||..||.:|||||||||||||.:..|.|:||||
Worm   448 VDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQWKLEDLFNLDSSEYKEA 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	61/90 (68%)
		PTKc_Frk_like	1319..1587	CDD:270653	181/268 (68%)
		Pkinase_Tyr	1328..1580	CDD:285015	170/252 (67%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	6/50 (12%)
		SH2_Src_Src42	120..215	CDD:198233	61/94 (65%)
		PTKc_Frk_like	231..496	CDD:270653	181/268 (68%)
		Pkinase_Tyr	240..489	CDD:285015	170/252 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159733
Domainoid	1	1.000	356	1.000	Domainoid score	I512
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	621	1.000	Inparanoid score	I480
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	1	1.010	-	-		QHG52589
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto18231
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890