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Protein Alignment Src42A and Jak2

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001041642.1	Gene:	Jak2 / 16452	MGIID:	96629	Length:	1132	Species:	Mus musculus

Alignment Length:	1178	Identity:	252/1178 - (21%)
Similarity:	409/1178 - (34%)	Gaps:	408/1178 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 RNYKECLTQSRNRRKSY----EEFKAMFIEPPAEASKSVTVPPPVVAPADDATTASSTVIPLSSI 591
            :.:.:|...:||.:..|    |..::.|.....|..:|..      .|:.:...|:..:.....|
Mouse   238 QQFSQCKATARNLKLKYLINLETLQSAFYTEQFEVKESAR------GPSGEEIFATIIITGNGGI 296

  Fly   592 -------SEQENIGSRGV---------------RGKPDCANEFTASTDEMDTGDGNSDGEKGAAA 634
                   .|.|.:..:.|               :...:|:||....|...         :.|...
Mouse   297 QWSRGKHKESETLTEQDVQLYCDFPDIIDVSIKQANQECSNESRIVTVHK---------QDGKVL 352

  Fly   635 EVDLTTETTATAKTLVSSSTTEAMRKNSDFLSQILDHQFAAKERAKAHKRRTSYEEFKRLVNEIE 699
            |::|             ||..||:    .|:| ::|..:  :..|.||         ..|..|:.
Mouse   353 EIEL-------------SSLKEAL----SFVS-LIDGYY--RLTADAH---------HYLCKEVA 388

  Fly   700 PLECPNTQPTVSAAVTPTTATAAAAASLIKRQNSR-------QRKSFASYFLP---HRHSTKEQK 754
            |   |.....:.:......:...|.:.|.|..|..       ..|.|..|||.   .|.:..|.|
Mouse   389 P---PAVLENIHSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK 450

  Fly   755 ----TEKENCSRDPIKPSQEQQLAVCGKLPL-----HRSNTSDISSSYYRRNF------------ 798
                |:.||                 |:..|     :.||..|:.:.|.....
Mouse   451 HCLITKNEN-----------------GEYNLSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKC 498

  Fly   799 ---KIYDK---LVYGT--IYDI-----IQRKNDIYQKYDKYMTYGTIYEILHRKTSQSSDPWQRK 850
               |..||   ||:.|  |.|:     :||.|::.|.            :.|:..::
Mouse   499 CPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVNQM------------VFHKIRNE-------- 543

  Fly   851 SLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINPHKYGTIYDILQGVKIDAGHVKN 915
                         |:|::         .:||.              ||...|.:||:.:.|..
Mouse   544 -------------DLIFN---------ESLGQ--------------GTFTKIFKGVRREVGDY-- 570

  Fly   916 KPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSVQEQGAPKSNKPNKMRRLSNILSYS- 979
              .|..|                  ..|.:...|::.::..|.....::..:::.....:|:|.
Mouse   571 --GQLHK------------------TEVLLKVLDKAHRNYSESFFEAASMMSQLSHKHLVLNYGV 615

  Fly   980 RNSGEDQ---QETT--GKEETKPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRGLDKEHSQEP 1039
            ...||:.   ||..  |..:|..|:.  |..|   |:|..|              |:.|:.:...
Mouse   616 CVCGEENILVQEFVKFGSLDTYLKKN--KNSI---NILWKL--------------GVAKQLAWAM 661

  Fly  1040 ---EEKCASEEQMCTRNAL--------TKSSSLDAIS---LSVAISPASSPSPPRPRRSLKQHR- 1089
               |||......:|.:|.|        |.:.....:|   :|:.:.|          :.:.|.|
Mouse   662 HFLEEKSLIHGNVCAKNILLIREEDRRTGNPPFIKLSDPGISITVLP----------KDILQERI 716

  Fly  1090 ------CLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLTAIEK 1148
                  |::..:...||..                    :||..|.|...|  :..:.||:|::.
Mouse   717 PWVPPECIENPKNLNLATD--------------------KWSFGTTLWEIC--SGGDKPLSALDS 759

  Fly  1149 SRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFR 1213
            .|.|                                                  :|..:|
Mouse   760 QRKL--------------------------------------------------QFYEDK----- 769

  Fly  1214 KIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFR 1278
                    .:|..|:....|.||.:.    .||                   |..|..|.|...|
Mouse   770 --------HQLPAPKWTELANLINNC----MDY-------------------EPDFRPAFRAVIR 803

  Fly  1279 TLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDV- 1342
            .|..|   ::.|.:.|..|...|.::|......| :...||..:.:...|||:::||.|.||.|
Mouse   804 DLNSL---FTPDYELLTENDMLPNMRIGALGFSG-AFEDRDPTQFEERHLKFLQQLGKGNFGSVE 864

  Fly  1343 ---WEGLWNNT-TPVAIKTLKSGTMDP-KDFLAEAQIMKKLRHTKLIQLYAVC--TVEEPIYIIT 1400
               ::.|.:|| ..||:|.|:..|.:. :||..|.:|:|.|:|..:::...||  .....:.:|.
Mouse   865 MCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIM 929

  Fly  1401 ELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVK 1465
            |.:.:|||.:|||  ..|.| :..:.|:...:||..||.||.::.|||||||.||:||.:.|.||
Mouse   930 EYLPYGSLRDYLQ--KHKER-IDHKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVK 991

  Fly  1466 IADFGLARLIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTY------ 1522
            |.||||.:::.:|:  |:.:.....||.|.|||:...||||:.|||||||::|.||.||
Mouse   992 IGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKS 1056

  Fly  1523 ---------GRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQW 1578
                     |......|....::..::...|:|:|..|...:|.||.|||:.:..:||:|..|..
Mouse  1057 PPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSFRDLSL 1121

  Fly  1579 KLEDFYTS 1586
            :::....|
Mouse  1122 RVDQIRDS 1129

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.