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Protein Alignment Src42A and Jak1

DIOPT Version :10

Sequence 1:	NP_001400996.1	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1606	Species:	Drosophila melanogaster
Sequence 2:	NP_666257.2	Gene:	Jak1 / 16451	MGIID:	96628	Length:	1153	Species:	Mus musculus

Alignment Length:	1113	Identity:	250/1113 - (22%)
Similarity:	401/1113 - (36%)	Gaps:	359/1113 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   747 RHSTKEQKTEKENCSRDP-----IKPSQEQQLAVCGK-------LPLHRSNTS----DISS---- 791
            |||.|:||...|. .|.|     :..|..:.|...|:       .|:....|.    ||.:
Mouse   128 RHSPKKQKNGYEK-KRVPEATPLLDASSLEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLG 191

  Fly   792 ------SYYRRNFKI----------YDKLVYGTIYDIIQRK--------NDIYQKYDKYMTYGTI 832
                  |:|....|:          |.:.:..|:...|:::        |::::.:.|.....||
Mouse   192 MAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTI 256

  Fly   833 YEILHRKTSQSSDPWQRKSLSSILEGGRSSGDIIYDIGQRRERDKRTLGSSSSATVSTINPHKYG 897
            .:     :|.|:...:.|.|:::....:..|..|::...        |..||...:|..:.:..|
Mouse   257 CD-----SSVSTHDLKVKYLATLETLTKHYGAEIFETSM--------LLISSENELSRCHSNDSG 308

  Fly   898 TI-YDILQGVKIDAGHV----KNKPDQKSKPTKPPLAKPTRFVVSQVVEPVQIPPTDQSGKSVQE 957
            .: |:::.     .|::    :.||:                     |.||:........|.::.
Mouse   309 NVLYEVMV-----TGNLGIQWRQKPN---------------------VVPVEKEKNKLKRKKLEY 347

  Fly   958 QGAPKSNKPNKMRRLSNILSY----SRNSGEDQQETTGKEETKPKRTQAKRRIGVTNLLLPLDSE 1018
            ....|.::.||:|...|..||    :....::...:..|::.|             |:.|.|.|.
Mouse   348 NKHKKDDERNKLREEWNNFSYFPEITHIVIKESVVSINKQDNK-------------NMELKLSSR 399

  Fly  1019 EL----------YTRIIAQQRGLDKEH-----------SQEPEEKCASEEQMCTRNALTK----- 1057
            |.          |.|:.|     |..|           ....:..|  ...:||..|:.|
Mouse   400 EEALSFVSLVDGYFRLTA-----DAHHYLCTDVAPPLIVHNIQNGC--HGPICTEYAINKLRQEG 457

  Fly  1058 -----------SSSLDAISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKH-SLDN--C 1108
                       .:..|.|.::|.....|.....:     ||.:..|...|......| |:|:  .
Mouse   458 SEEGMYVLRWSCTDFDNILMTVTCFEKSEVLGGQ-----KQFKNFQIEVQKGRYSLHGSMDHFPS 517

  Fly  1109 LQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELP--LTAIEKSRSLPAACSASCSHTCAHLS--- 1168
            |:.:.:...:|.||..:....||..|.|...|:.  |.|.:|::......|.|      .||
Mouse   518 LRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQPVYSMS------QLSFDR 576

  Fly  1169 VIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKLLLPENE--- 1230
            ::.:.....:..|:.:.|....|   .|.::...|.:.|:       |:|:...|:|.|.:.
Mouse   577 ILKKDIIQGEHLGRGTRTHIYSG---TLLDYKDEEGIAEE-------KKIKVILKVLDPSHRDIS 631

  Fly  1231 ----HGAFLIRDSESRH--NDYSLSVRDGDTVKHYRIRQLDEGG---FFIARR----TT---FRT 1279
                ..|.::|....:|  ..|.:.|||   |::..:.:..|||   .|:.|:    ||   |:.
Mouse   632 LAFFEAASMMRQVSHKHIVYLYGVCVRD---VENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKV 693

  Fly  1280 LQELVE--HYSKDSDGLCVNLC------------------------------------------- 1299
            .::|..  .|.:|.|.:..|:|
Mouse   694 AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIERIPWI 758

  Fly  1300 -KPCVQTNS-------------------FSGVFEIE---------------KPVTEG-------- 1321
             ..||:.:.                   ::|...::               :|||..
Mouse   759 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLM 823

  Fly  1322 -----------------------LSHRTRD-------QWEIDRTS-----LKFVRKLGSGQFGDV 1351
                                   |..:..|       ..|:|.|.     ||.:|.||.|.||.|
Mouse   824 TRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKQPTTEVDPTHFEKRFLKRIRDLGEGHFGKV 888

  Fly  1352 ----WEGLWNNT-TPVAIKTLK--SGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVE--EPIYI 1407
                ::...:|| ..||:|:||  ||.....|...|.:|::.|.|..:::...:|..:  ..|.:
Mouse   889 ELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKL 953

  Fly  1408 ITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNI 1472
            |.|.:..|||.|||.....| .:||.|  :..|.||..||.||.|:.|:|||||||||||...:.
Mouse   954 IMEFLPSGSLKEYLPKNKNK-INLKQQ--LKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQ 1015

  Fly  1473 VKIADFGLARLIKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTY---- 1531
            |||.||||.:.|:.|:  |..:.....|:.|.|||.....||.|.|||||||:.|.||:||
Mouse  1016 VKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD 1080

  Fly  1532 -----------GRIPYPG-MTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFET 1584
                       |  |..| ||...::..::.|.|:|.||||...:|::|.:||...|..|.||:.
Mouse  1081 FSPMALFLKMIG--PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQN 1143

  Fly  1585 LQWKLEDF 1592
            |   :|.|
Mouse  1144 L---IEGF 1148

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.