Protein Alignment Src42A and Jak1

DIOPT Version :9

• Sequence 1: NP_610191.2
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1597
• Species: Drosophila melanogaster
• Sequence 2: NP_666257.2
• Gene: Jak1 / 16451
• MGIID: 96628
• Length: 1153
• Species: Mus musculus
• Alignment Length: 582
• Identity: 163/582 - (28%)
• Similarity: 228/582 - (39%)
• Gaps: 176/582 - (30%)

  Fly  1040 EEKCASEEQMCTRNALTKSSSLDA-----ISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPL 1099
            |:|......:||:|.|.....:|:     |.||         .|..|...|.:..|:   ::.|.
Mouse   705 EDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLS---------DPGIPVSVLTRQECI---ERIPW 757

  Fly  1100 AKKHSLDNC--LQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPL---TAIEKSRSLPAACSAS 1159
            .....:::.  |.|.:.        :||..|.|...|:  ..|:||   |.|||.|...:.|
Mouse   758 IAPECVEDSKNLSVAAD--------KWSFGTTLWEICY--NGEIPLKDKTLIEKERFYESRC--- 809

  Fly  1160 CSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAEKKL 1224
                         .|.|..|                                          |:|
Mouse   810 -------------RPVTPSC------------------------------------------KEL 819

  Fly  1225 LLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSK 1289
                        .|..:|..:|..:.|.                ||   |...|.:.:|.|.
Mouse   820 ------------ADLMTRCMNYDPNQRP----------------FF---RAIMRDINKLEEQ--- 850

  Fly  1290 DSDGLCVNLCKPCVQIEK-PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDV----WEGLWNN 1349
                      .|.:..|| |.||      .|....::..||.:|.||.|.||.|    ::...:|
Mouse   851 ----------NPDIVSEKQPTTE------VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN 899

  Fly  1350 T-TPVAIKTLK--SGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVE--EPIYIITELMKHGSLL 1409
            | ..||:|:||  ||.....|...|.:|::.|.|..:::...:|..:  ..|.:|.|.:..|||.
Mouse   900 TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLK 964

  Fly  1410 EYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARL 1474
            |||.....| .:||.|  :..|.||..||.||.|:.|:|||||||||||...:.|||.||||.:.
Mouse   965 EYLPKNKNK-INLKQQ--LKYAIQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKA 1026

  Fly  1475 IKEDE--YEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTY--------------- 1522
            |:.|:  |..:.....|:.|.|||.....||.|.|||||||:.|.||:||
Mouse  1027 IETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDFSPMALFLKMI 1091

  Fly  1523 GRIPYPG-MTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDF 1583
            |  |..| ||...::..::.|.|:|.||||...:|::|.:||...|..|.||:.|   :|.|
Mouse  1092 G--PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNL---IEGF 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	12/90 (13%)
		PTKc_Frk_like	1319..1587	CDD:270653	111/292 (38%)
		Pkinase_Tyr	1328..1580	CDD:285015	108/278 (39%)
Jak1	NP_666257.2	FERM_F1	<52..129	CDD:408179
		FERM_F2	147..277	CDD:408177
		FERM_C_JAK1	282..426	CDD:275412
		SH2_Jak1	426..526	CDD:198241
		PTK_Jak1_rpt1	582..845	CDD:270662	44/250 (18%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	110/288 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910