DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and CSK

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001120662.1	Gene:	CSK / 1445	HGNCID:	2444	Length:	450	Species:	Homo sapiens

Alignment Length:	399	Identity:	167/399 - (41%)
Similarity:	228/399 - (57%)	Gaps:	38/399 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1202 GEFLNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIR---- 1262
            |..|:...|:..||.|.:||:.|..||.  |.||:|:|.:...||:|.|.....|:||||.
Human    74 GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS 136

  Fly  1263 --QLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGL----SHRTRDQW 1321
              .:||       ...|..|.:|||||:.|:||||..|.||      .|.||.    ....|..|
Human   137 KLSIDE-------EVYFENLMQLVEHYTSDADGLCTRLIKP------KVMEGTVAAQDEFYRSGW 188

  Fly  1322 EIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQL 1386
            .::...||.::.:|.|:||||..|.:.. ..||:|.:|:.. ..:.|||||.:|.:|||:.|:||
Human   189 ALNMKELKLLQTIGKGEFGDVMLGDYRG-NKVAVKCIKNDA-TAQAFLAEASVMTQLRHSNLVQL 251

  Fly  1387 YAVCTVEEP--IYIITELMKHGSLLEYLQAIAGKGRS-LKMQTLIDMAAQIAAGMAYLESQNYIH 1448
            ..| .|||.  :||:||.|..|||::||::   :||| |....|:..:..:...|.|||..|::|
Human   252 LGV-IVEEKGGLYIVTEYMAKGSLVDYLRS---RGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVH 312

  Fly  1449 RDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFG 1513
            ||||||||||.:.|:.|::||||.   ||.......| :.|:|||||||....|||.||||||||
Human   313 RDLAARNVLVSEDNVAKVSDFGLT---KEASSTQDTG-KLPVKWTAPEALREKKFSTKSDVWSFG 373

  Fly  1514 ILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQW 1578
            |||.|:.::||:|||.:...:|:.:||.||:|..|..|.|.:||:|..|||.|...||:|..|:.
Human   374 ILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLRE 438

  Fly  1579 KLEDFYTSD 1587
            :||...|.:
Human   439 QLEHIKTHE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	38/96 (40%)
		PTKc_Frk_like	1319..1587	CDD:270653	121/270 (45%)
		Pkinase_Tyr	1328..1580	CDD:285015	117/254 (46%)
CSK	NP_001120662.1	Interaction with PTPN22. /evidence=ECO:0000250\|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	41/111 (37%)
		PTKc_Csk	188..443	CDD:133213	120/264 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910