DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and Frk

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	388	Identity:	251/388 - (64%)
Similarity:	305/388 - (78%)	Gaps:	5/388 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGF 1269
            |..:.|:|..|||.:|||:||..||:.||||||:|||:..|:||||.|...|||||||:||||||
Mouse   118 LQAEPWFFGAIKRADAEKQLLYSENQTGAFLIRESESQKGDFSLSVLDEGVVKHYRIRRLDEGGF 182

  Fly  1270 FIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVRKL 1334
            |:.||..|.||.|.|.:|:..||||||.|.|||::|:.|....||::|.|||||||.|::.:::|
Mouse   183 FLTRRKVFSTLNEFVNYYTTTSDGLCVKLEKPCLKIQVPTPFDLSYKTADQWEIDRNSIQLLKRL 247

  Fly  1335 GSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYII 1399
            ||||||:|||||||||||||:||||.|:|||.|||.||||||.|||.||||||||||:|:|||||
Mouse   248 GSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYII 312

  Fly  1400 TELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIV 1464
            ||||:||||.||||...|....|..|  :|||||:|:|||||||||||||||||||||||:.||.
Mouse   313 TELMRHGSLQEYLQNDGGSKIHLIQQ--VDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIY 375

  Fly  1465 KIADFGLARLIK---EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIP 1526
            |:|||||||:.|   ||.||::...:.|:|||||||...:|||||||||||||||.|::|||::|
Mouse   376 KVADFGLARVFKVDNEDIYESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMP 440

  Fly  1527 YPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQS 1589
            |.|||.|:|:..:...||:|||.||..:.|.||||||:.:|.:|||||||.|||||::.:|.|
Mouse   441 YSGMTGAQVIQMLSQNYRLPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYFETDCS 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	56/90 (62%)
		PTKc_Frk_like	1319..1587	CDD:270653	184/270 (68%)
		Pkinase_Tyr	1328..1580	CDD:285015	172/254 (68%)
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779
		SH2_Src_Frk	119..214	CDD:199831	56/94 (60%)
		PTKc_Frk_like	232..501	CDD:270653	184/270 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	362	1.000	Domainoid score	I946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48065
Inparanoid	1	1.050	592	1.000	Inparanoid score	I972
Isobase	1	0.950	-	0	Normalized mean entropy	S1714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto92560
orthoMCL	1	0.900	-	-		OOG6_108172
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3556
SonicParanoid	1	1.000	-	-		X5849
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.950