Protein Alignment Src42A and Bmx

DIOPT Version :10

• Sequence 1: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_033889.2
• Gene: Bmx / 12169
• MGIID: 1101778
• Length: 655
• Species: Mus musculus
• Alignment Length: 707
• Identity: 207/707 - (29%)
• Similarity: 329/707 - (46%)
• Gaps: 114/707 - (16%)

  Fly   949 DQSGKSVQEQGAPKSNKPNKMRRLSNI-----------LSYSRNSGEDQQETTGKEETKPKRTQA 1002
            :...||:.|:...|.::..|....:|.           |||.......:....|..|.|..|...
Mouse     4 NMESKSILEELLLKKSQQKKKMSPNNYKERLFVLTKTSLSYYEYDKMKRGSRKGSIEIKKIRCVE 68

  Fly  1003 KRRIGVTNLLLPLDSEELYTRIIAQQRGLDKEHSQEPEEKC----ASEEQ--------------- 1048
            |     .||......|..|...|..:.||...::...|.:|    |.:::
Mouse    69 K-----VNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRCQWLKALQKEIRGNPHLLIKYHSGF 128

  Fly  1049 ------MCTRNALTKSSSLDA----ISLSVAISPASSPSPPRPRRSLKQHRCLQQHQQTPLAKKH 1103
                  :|.:.:...:.....    ..|.:|||.....:|..|.|.||..|.:      |:.|
Mouse   129 FVDGKFLCCQQSCKAAPGCTLWEAYADLHIAISDEKHRAPTFPERLLKIPRAV------PVLK-- 185

  Fly  1104 SLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPAT-------EELP-LTAIEKSRS-LPAACSAS 1159
                    :.:::|...|.::.:.:...|...|.:       |:.| ...:.|.:| ...|||..
Mouse   186 --------MDASSSGAILPQYDSYSKKSCGSQPTSNIRYIPREDCPDWWQVRKLKSEEDIACSNQ 242

  Fly  1160 CSHTCAHLSVIDQSPATTKC---FGKTSLTTAKKGKSRRLSEFTRGEFLNEKSWYFRKIKRIEAE 1221
            .....|       |.:|:|.   |.::|.:..:             |.|:...|:...|.|.::|
Mouse   243 LERNIA-------SHSTSKMSWGFPESSSSEEE-------------ENLHAYDWFAGNISRSQSE 287

  Fly  1222 KKLLLPENEHGAFLIRDSESRHNDYSLS-----VRD-GDTVKHYRIRQLDEGGFFIARRTTFRTL 1280
             :||..:.:.|||::|:| |:...|::|     |.| ..|||||.:....|...::|....|.::
Mouse   288 -QLLRQKGKEGAFMVRNS-SQMGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSI 350

  Fly  1281 QELVEHYSKDSDGLCVNLCKPCVQTNSFSGVFEIEKPVTEGLSHRTRDQWEIDRTSLKFVRKLGS 1345
            .:|:.::..:|.|:...|..| |.|.:      .:.||:..|....   ||:.|..:..:::||:
Mouse   351 PKLIHYHQHNSAGMITRLRHP-VSTKA------NKVPVSVALGSGI---WELKREEITLLKELGN 405

  Fly  1346 GQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITE 1410
            ||||.|..|.|.....||:|.:|.|.|...:|..|||.|.||.|.||::.|.||:.:.||||:||
Mouse   406 GQFGVVQLGQWKGQYDVAVKMIKEGAMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTE 470

  Fly  1411 LMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKI 1475
            .:.:|.||.||::   .|:.|:...|::|...:..|||:|||..:|||||||||.||.....||:
Mouse   471 YITNGCLLNYLKS---HGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKV 532

  Fly  1476 ADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMT 1540
            :|||:.|.:.:|:|.:.||.:||:||:|||..:|.|:|.|||||:||||:.|:.:.|:.||....
Mouse   533 SDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYD 597

  Fly  1541 NAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQ 1597
            |:||:.:|..|:|:.:|......:|:||..|||:.|.:||||:.|...:|.....|:
Mouse   598 NSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPLREQDK 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	28/96 (29%)
		PTKc_Frk_like	1328..1596	CDD:270653	116/267 (43%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944	20/130 (15%)
		SH2_Tec_Bmx	269..374	CDD:198262	32/107 (30%)
		Protein Kinases, catalytic domain	392..647	CDD:473864	113/257 (44%)