DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and GRAP

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	NP_006604.1	Gene:	GRAP / 10750	HGNCID:	4562	Length:	217	Species:	Homo sapiens

Alignment Length:	100	Identity:	36/100 - (36%)
Similarity:	57/100 - (56%)	Gaps:	4/100 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly  1190 KGKSRRLSEFTRGEFLNEK--SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD 1252
            |.:.|.:..|....::..|  .||..:|.|..|| ::|:..|..||||||:|||...::|:||..
Human    38 KAELRGVEGFIPKNYIRVKPHPWYSGRISRQLAE-EILMKRNHLGAFLIRESESSPGEFSVSVNY 101

  Fly  1253 GDTVKHYRIRQLDEGGFFIARRTTFRTLQELVEHY 1287
            ||.|:|:::.:...|.:|:... .|.:|.|||:.|
Human   102 GDQVQHFKVLREASGKYFLWEE-KFNSLNELVDFY 135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	31/77 (40%)
		PTKc_Frk_like	1319..1587	CDD:270653
		Pkinase_Tyr	1328..1580	CDD:285015
GRAP	NP_006604.1	SH3_GRAP_N	2..55	CDD:212881	3/16 (19%)
		SH2_Grb2_like	56..150	CDD:199828	32/81 (40%)
		SH3_GRAP_C	162..214	CDD:212884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910