DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and hck

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_005174178.1	Gene:	hck / 101885596	ZFINID:	ZDB-GENE-090313-72	Length:	499	Species:	Danio rerio

Alignment Length:	521	Identity:	244/521 - (46%)
Similarity:	327/521 - (62%)	Gaps:	54/521 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1095 QQTPLAKKHSLDNCLQVV----SSTTSRQPLRRWSN-QTPLKCTCHPATEELPLTAIEKSRSLPA 1154
            :|.|:.|..:.|:...|.    ..||..:..|..|| ||       |.|:.....||
Zfish     9 EQDPIGKSVNSDDNRNVAHYTKDPTTGAKANRTTSNAQT-------PGTDTSENIAI-------- 58

  Fly  1155 ACSASCSHTCAH-----------LSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEK 1208
               |...:...|           |.::.:|....|.   ..::|.::|...  |.:...:.|..:
Zfish    59 ---ALYDYEAMHEGDLGFKKGDRLRILQESGEWWKA---VIISTGQEGFIP--SNYVAKDTLETE 115

  Fly  1209 SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD----GDTVKHYRIRQLDEGGF 1269
            .|:|:.:.|.:||::||...|:.|:|:|||||:....|||||||    .||||||:||.||.|||
Zfish   116 EWFFKGVSRKDAERQLLASGNKTGSFMIRDSETTKGSYSLSVRDSDHQADTVKHYKIRTLDNGGF 180

  Fly  1270 FIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCV--QIEKPVTEGLSHRTRDQWEIDRTSLKFVR 1332
            :|:.|.||.|||:||.||.|.|||||.:|..||:  :.:||       ..:|.|||.|.|||..:
Zfish   181 YISPRITFNTLQDLVSHYKKQSDGLCQSLTSPCLSPKPQKP-------WEKDAWEIPRESLKLDK 238

  Fly  1333 KLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIY 1397
            :||:||||:||..::|..|.||:||:|.|:|..:.||.||.:||.|:|.||::|.||.|.|||||
Zfish   239 RLGAGQFGEVWMAMYNKHTKVAVKTMKPGSMSVEAFLMEANLMKSLQHDKLVRLNAVVTKEEPIY 303

  Fly  1398 IITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGN 1462
            ||||.|:.||||::::  :.:|..:::..|||.:||||.||||:|.:|||||||.|.|:||....
Zfish   304 IITEFMEKGSLLDFIK--SDEGNRVQLPKLIDFSAQIAEGMAYIEQRNYIHRDLRAANILVNKSL 366

  Fly  1463 IVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPY 1527
            :.|||||||||:|:::||.||.||:||||||||||.||..|:||||||||||||||:::|||.||
Zfish   367 VCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPY 431

  Fly  1528 PGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSDYK 1592
            |||||.||:..:|.||||.:..:|...||:||||||...|..|||||.||..||||||:.:|.|:
Zfish   432 PGMTNPEVIRALERGYRMQRLDSCPQELYDIMLECWKNKPEDRPTFEYLQSVLEDFYTATESQYQ 496

  Fly  1593 E 1593
            :
Zfish   497 Q 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	53/94 (56%)
		PTKc_Frk_like	1319..1587	CDD:270653	160/267 (60%)
		Pkinase_Tyr	1328..1580	CDD:285015	148/251 (59%)
hck	XP_005174178.1	SH3	58..109	CDD:302595	9/66 (14%)
		SH2	113..215	CDD:301589	55/101 (54%)
		PTKc_Hck	222..487	CDD:270658	156/266 (59%)
		Pkinase_Tyr	234..484	CDD:285015	148/251 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I6487
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920