DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Src42A and ptk6

DIOPT Version :9

Sequence 1:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	388	Identity:	175/388 - (45%)
Similarity:	236/388 - (60%)	Gaps:	8/388 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRDGDTVKHYRIRQLDEGGF 1269
            :.|:.|:|.:..|.||...|:...|.:|:||||.|:.....|.||||..|:.:|::|.:..||.|
Frog   165 VEEQEWFFGEKSRTEAVNLLMDEGNTNGSFLIRASDKHGILYVLSVRHQDSTRHFKIMRNPEGQF 229

  Fly  1270 FIARRTTFRTLQELVEHYSKDSDGLC--VNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLKFVR 1332
            .:...|.|..|::|||.|.|..  :|  :.|.||||:.| ||...||....|:||..|.....|:
Frog   230 HLNNMTFFPDLKQLVETYCKKP--ICPGLTLTKPCVKNE-PVVSDLSPVPLDEWERPREEFTLVK 291

  Fly  1333 KLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIY 1397
            :||.|.||.|.||||.....||:||:|........|:.|...:|.|.|..|:.|||||:|.:|.|
Frog   292 RLGMGNFGQVHEGLWKGKLKVAVKTIKRDATSQDLFVKETAFLKTLHHKNLLSLYAVCSVGDPYY 356

  Fly  1398 IITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDGN 1462
            |:|||:..|.||.||:.:  :...|.::..:|:|.|:|.||.||||||.|||||||||||:|..|
Frog   357 IVTELVPRGDLLNYLRDL--EKDELDVEGQLDIATQVAEGMRYLESQNCIHRDLAARNVLMGRNN 419

  Fly  1463 IVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPY 1527
            |.||||||:||:|. |.|........|.|||||||..|.::::|||||||||||.|:::.|..||
Frog   420 ICKIADFGMARVIL-DSYYVSASKEIPFKWTAPEAVEYGRYTVKSDVWSFGILLYEIMSLGMQPY 483

  Fly  1528 PGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQSD 1590
            |.::|.|||..:..|.||..||:|..|:|.|||.||..:|..||:|:.|:..||:....:.|:
Frog   484 PALSNYEVLEFLNRGQRMKAPPSCSTRVYNIMLTCWAWNPNERPSFDDLRTMLENLSNYEGSE 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	34/92 (37%)
		PTKc_Frk_like	1319..1587	CDD:270653	130/267 (49%)
		Pkinase_Tyr	1328..1580	CDD:285015	124/251 (49%)
ptk6	XP_002942429.3	SH3	104..161	CDD:418401
		SH2	168..252	CDD:214585	32/85 (38%)
		STYKc	288..536	CDD:214568	124/250 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920